Ferroptosis mechanism and Alzheimer's disease

被引：15

作者：

Feng, Lina ^{[1
]}

Sun, Jingyi ^{[1
]}

Xia, Ling ^{[1
]}

Shi, Qiang ^{[1
]}

Hou, Yajun ^{[1
]}

Zhang, Lili ^{[2
]}

Li, Mingquan ^{[3
]}

Fan, Cundong ^{[1
]}

Sun, Baoliang ^{[1
]}

机构：

[1] Shandong First Med Univ, Shandong Key Lab TCM Multitarget Intervent & Dis C, Affiliated Hosp 2, Tai An, Shandong, Peoples R China

[2] Taian Traff Hosp, Dept Internal Med, Tai An, Shandong, Peoples R China

[3] Changchun Univ Chinese Med, Dept Neurol, Affiliated Clin Hosp 3, Changchun, Jilin, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2024年 / 19卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; apolipoprotein E; Fe2+; ferroptosis; glial cell; glutathione peroxidase 4; imbalance in iron homeostasis; lipid peroxidation; regulated cell death; system Xc(-); HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; PROGRESSIVE SUPRANUCLEAR PALSY; CELL-DEATH; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; A-BETA; TAU PHOSPHORYLATION; HEME OXYGENASE-1; INFLAMMATORY RESPONSES; COGNITIVE IMPAIRMENT;

D O I：

10.4103/1673-5374.389362

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms. This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms. Ferroptosis is a classic regulatory mode of cell death. Extensive studies of regulatory cell death in Alzheimer's disease have yielded increasing evidence that ferroptosis is closely related to the occurrence, development, and prognosis of Alzheimer's disease. This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferroptosis in Alzheimer's disease. Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer's disease.

引用

页码：1741 / 1750

页数：10

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