Nanoparticles and Bioconvection with microorganisms have inclusive and widespread of applications in the specialty of engineering, bioinformatics, biotechnology, mechanical energy and biosensors. Likewise, widespread utilization in diverse industries for-instance, geothermal technology, bio-medical, microelectronics, mechanical-chemistry, solar cells, chlorofluorocarbons toward nuclear reactors and exploitation, together along product degeneration, nuclear reactor chilling, oil emulsification and the thrust in the thermal conductivity accom-plishment of the fluid, nuclear plant cooling has flourish an contemporary area for scientists and research scalars. The foremost manifesto of the existing investigation is to provide mathematical modeling and numerical simulation of the three-dimensional steady Bioconvection flow of Carreau nanofluids under the impact of nonlinear radiation and gyrotactic microorganisms. Furthermore, magnetohydrodynamic, activation energy and mixed convection inspirations are also measured. We constrained boundary layer theory to advance the basic PDEs for microorganism field, nanoparticle concentration, energy, momentum and mass, and thus condensed to extremely nonlinear ODEs by using the variable transformations. To scrutinize the problem, we acquired the numerical solution for present study with the help of bvp4c, a MATLAB practice. Graphical along with numerical consequences for the Sherwood number, density number of microorganism and wall heat transfer are as well accompanied. It is fascinating to note that microorganism field has been expanded due to having higher estimates of the bioconvection Peclet number and bioconvection Rayleigh number. It is also illustrated that higher values of heat generation/absorption parameter deteriorate the fluid temperature.