Are Janus kinase inhibitors an effective treatment for palmoplantar pustulosis? A critically appraised topic

被引:5
|
作者
Gleeson, David [1 ,2 ]
Barker, Jonathan N. W. N. [3 ]
Capon, Francesca [4 ]
Pink, Andrew E. [1 ,2 ]
Woolf, Richard T. [1 ,2 ]
Smith, Catherine H. [1 ,2 ]
Mahil, Satveer K. [1 ,2 ]
机构
[1] Guys & St ThomasNHS Fdn Trust, St Johns Inst Dermatol, London SE1 9RT, England
[2] Kings Coll London, London SE1 9RT, England
[3] Kings Coll London, St Johns Inst Dermatol, Fac Life Sci & Med, London SE1 7EP, England
[4] Kings Coll London, Dept Med & Mol Genet, London SE1 9RT, England
基金
美国国家卫生研究院;
关键词
JAK INHIBITOR; ARTHRITIS; TOFACITINIB; PSORIASIS;
D O I
10.1093/bjd/ljac130
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
We carried out a critical appraisal of the literature to assess whether Janus kinase inhibitors are an effective treatment for palmoplantar pustulosis, a rare and debilitating form of psoraisis. Our appraisal identified case reports and case series of 16 patients who have been treated to good effect with tofacitinib, indicating this may be a promising therapeutic option. However, routine use of janus kinase inhibitors cannot be recommended outside the context of a clinical trial given the current low-quality of evidence available and the uncertain safety profile of Janus kinase inhibitors.
引用
收藏
页码:471 / 473
页数:3
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