Non-canonical DNA structures in the human ribosomal DNA

被引：5
|
作者：
Smirnov, Evgeny [1 ,2 ]
Molinova, Pavla [1 ,2 ]
Chmurciakova, Nikola [1 ,2 ]
Vacik, Tomas [1 ,2 ]
Cmarko, Dusan [1 ,2 ]
机构：
[1] Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Lab Cell Biol, Prague 12800, Czech Republic
[2] Gen Univ Hosp Prague, Prague 12800, Czech Republic
来源：
HISTOCHEMISTRY AND CELL BIOLOGY | 2023年 / 160卷 / 06期
关键词：
rDNA; Non-canonical DNA; R-loops; DNA quadruplexes; I-MOTIF STRUCTURES; HUMAN C-MYC; G-QUADRUPLEX; FORMING SEQUENCES; TRANSCRIPTION FACTOR; R-LOOPS; B-DNA; HETEROCHROMATIN FORMATION; NEGATIVE SUPERHELICITY; NUCLEOLAR LOCALIZATION;
D O I：
10.1007/s00418-023-02233-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Non-canonical structures (NCS) refer to the various forms of DNA that differ from the B-conformation described by Watson and Crick. It has been found that these structures are usual components of the genome, actively participating in its essential functions. The present review is focused on the nine kinds of NCS appearing or likely to appear in human ribosomal DNA (rDNA): supercoiling structures, R-loops, G-quadruplexes, i-motifs, DNA triplexes, cruciform structures, DNA bubbles, and A and Z DNA conformations. We discuss the conditions of their generation, including their sequence specificity, distribution within the locus, dynamics, and beneficial and detrimental role in the cell.
引用
收藏
页码：499 / 515
页数：17
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