Porous Mg-Zn-Ca scaffolds for bone repair: a study on microstructure, mechanical properties and in vitro degradation behavior

被引：2
|
作者：
Huo, Lei [1 ]
Li, Qiang [2 ]
Jiang, Linlin [2 ]
Jiang, Huiqin [2 ]
Zhao, Jianping [1 ]
Yang, Kangjian [1 ]
Dong, Qiangsheng [3 ]
Shao, Yi [2 ,4 ]
Chu, Chenglin [2 ,4 ]
Xue, Feng [2 ,4 ]
Bai, Jing [2 ,4 ,5 ]
机构：
[1] Taixing Second Peoples Hosp, Taizhou 225411, Peoples R China
[2] Southeast Univ, Sch Mat Sci & Engn, Jiangsu Key Lab Adv Met Mat, Nanjing 211189, Peoples R China
[3] Nanjing Inst Technol, Sch Mat Sci & Engn, Jiangsu Key Lab Adv Struct Mat & Applicat Technol, Nanjing 211167, Peoples R China
[4] Southeast Univ, Inst Med Devices Suzhou, Suzhou 215000, Peoples R China
[5] Nanjing Yunhai Special Met Co Ltd, Jiangsu Key Lab Light Met Alloys, Nanjing 211200, Peoples R China
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2024年 / 35卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Bone tissue engineering; Porous Mg-based scaffolds; Mechanical property; Degradability; MAGNESIUM; BIOMATERIALS; FABRICATION;
D O I：
10.1007/s10856-023-06754-y
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Biodegradable porous Mg scaffolds are a promising approach to bone repair. In this work, 3D-spherical porous Mg-1.5Zn-0.2Ca (wt.%) scaffolds were prepared by vacuum infiltration casting technology, and MgF2 and fluorapatite coatings were designed to control the degradation behavior of Mg-based scaffolds. The results showed that the pores in Mg-based scaffolds were composed of the main spherical pores (450-600 mu m) and interconnected pores (150-200 mu m), and the porosity was up to 74.97%. Mg-based porous scaffolds exhibited sufficient mechanical properties with a compressive yield strength of about 4.04 MPa and elastic modulus of appropriately 0.23 GPa. Besides, both MgF2 coating and fluorapatite coating could effectively improve the corrosion resistance of porous Mg-based scaffolds. In conclusion, this research would provide data support and theoretical guidance for the application of biodegradable porous Mg-based scaffolds in bone tissue engineering.
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页数：8
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