Response of the mosquito immune system and symbiotic bacteria to pathogen infection

被引:9
|
作者
Li, Manjin [1 ]
Zhou, Yang [2 ]
Cheng, Jin [1 ]
Wang, Yiqing [1 ]
Lan, Cejie [1 ]
Shen, Yuan [1 ,2 ]
机构
[1] Nanjing Med Univ, Affiliated Wuxi Ctr Dis Control & Prevent, Wuxi Ctr Dis Control & Prevent, Wuxi 214023, Peoples R China
[2] Nanjing Med Univ, Nanjing 211166, Peoples R China
关键词
Mosquito; Pathogen infection; Innate immune system; Immune priming; Symbiotic bacteria; COMPLEMENT-LIKE PROTEIN; NILE-VIRUS-INFECTION; ANOPHELES-GAMBIAE; AEDES-AEGYPTI; VECTOR COMPETENCE; PLASMODIUM-BERGHEI; SINDBIS VIRUS; SMALL RNA; FAT-BODY; ARBOVIRUS TRANSMISSION;
D O I
10.1186/s13071-024-06161-4
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Mosquitoes are the deadliest animal in the word, transmitting a variety of insect-borne infectious diseases, such as malaria, dengue fever, yellow fever, and Zika, causing more deaths than any other vector-borne pathogen. Moreover, in the absence of effective drugs and vaccines to prevent and treat insect-borne diseases, mosquito control is particularly important as the primary measure. In recent decades, due to the gradual increase in mosquito resistance, increasing attention has fallen on the mechanisms and effects associated with pathogen infection. This review provides an overview of mosquito innate immune mechanisms in terms of physical and physiological barriers, pattern recognition receptors, signalling pathways, and cellular and humoral immunity, as well as the antipathogenic effects of mosquito symbiotic bacteria. This review contributes to an in-depth understanding of the interaction process between mosquitoes and pathogens and provides a theoretical basis for biological defence strategies against mosquito-borne infectious diseases.
引用
收藏
页数:20
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