Glucose-dependent insulin production and insulin-independence in patients with type 1 diabetes infused with stem cell-derived, fully differentiated islet cells (VX-880)

被引:0
|
作者
Reichman, T. [1 ]
Ricordi, C. [2 ]
Naji, A. [3 ]
Markmann, J. F. [4 ]
Perkins, B. [5 ]
Bruinsma, B. G. [6 ]
Marigowda, G. [6 ]
Melton, D. [6 ]
Pagliuca, F. [6 ]
Sanna, B. [6 ]
Kean, L. S. [7 ,8 ]
Mathieu, C. [9 ]
Peters, A. [10 ]
Witkowski, P. [11 ]
Rickels, M. R. [3 ]
机构
[1] Toronto Gen Hosp, Toronto, ON, Canada
[2] Univ Miami, Miami, FL USA
[3] Univ Penn Perlman, Sch Med, Philadelphia, PA USA
[4] Massachusetts Gen Hosp, Boston, MA USA
[5] Mt Sinai Hosp, Toronto, ON, Canada
[6] Vertex Pharmaceut Inc, Boston, MA USA
[7] Boston Childrens Hosp, Boston, MA USA
[8] Dana Farber Canc Inst, Boston, MA USA
[9] Katholieke Univ Leuven, Leuven, Belgium
[10] Univ Southern Calif, Los Angeles, CA USA
[11] Univ Chicago, Chicago, IL USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
449
引用
收藏
页码:S229 / S230
页数:2
相关论文
共 50 条
  • [1] Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell-Derived, Fully Differentiated Islet Cells-Updated Data from the VX-880 Clinical Trial
    Reichman, Trevor W.
    Ricordi, Camillo
    Naji, Ali
    Markmann, James F.
    Perkins, Bruce A.
    Wijkstrom, Martin
    Paraskevas, Steven
    Bruinsma, Bote
    Marigowda, Gautham
    Shih, Judy L.
    Wang, Chenkun
    Melton, Douglas
    Pagliuca, Felicia
    Sanna, Bastiano
    Kean, Leslie S.
    Peters, Anne L.
    Witkowski, Piotr
    Rickels, Michael R.
    DIABETES, 2023, 72
  • [2] Improvement in glycaemic control and elimination of exogenous insulin use in patients with type 1 diabetes infused with fully differentiated islet cells (VX-880)
    Reichman, T.
    Witkowski, P.
    Markmann, J.
    Fung, J.
    Odorico, J.
    Wijkstrom, M.
    Kandeel, F.
    Kean, L.
    Mathieu, C.
    Peters, A.
    Bruinsma, B.
    Wang, C.
    Hong, J.
    Ricordi, C.
    Rickels, M.
    DIABETOLOGIA, 2024, 67 : S524 - S524
  • [3] STEM CELL-DERIVED, FULLY DIFFERENTIATED ISLET CELLS FOR TYPE 1 DIABETES
    Rickels, M.
    Ricordi, C.
    Naji, A.
    Bruinsma, B.
    Marigowda, G.
    Ross, L.
    Tan, Y. V.
    Pagliuca, F.
    Sanna, B.
    Kean, L.
    Peters, A.
    Witkowski, P.
    Markmann, J.
    DIABETES TECHNOLOGY & THERAPEUTICS, 2023, 25 : A81 - A81
  • [4] Stem Cell-Derived, Fully Differentiated Islet Cells for Type 1 Diabetes
    Markmann, James F.
    Naji, Ali
    Rickels, Michael R.
    Alba, Maria
    Marigowda, Gautham
    Ross, Leorah
    Wang, Chenkun
    Pagliuca, Felicia
    Sanna, Bastiano
    Kean, Leslie S.
    Peters, Anne L.
    Witkowski, Piotr
    Ricordi, Camillo
    DIABETES, 2022, 71
  • [5] Stem cell-derived, fully differentiated islet cells for type 1 diabetes
    Ricordi, C.
    Naji, A.
    Rickels, M. R.
    Bruinsma, B.
    Marigowda, G.
    Ross, L.
    Wang, C.
    Pagliuca, F.
    Sanna, B.
    Kean, L. S.
    Peters, A.
    Witkowski, P.
    Markmann, J.
    DIABETOLOGIA, 2022, 65 (SUPPL 1) : S196 - S197
  • [6] A Case of Continued Insulin-Independence 8 Years after Islet Cell Transplantation: A Promising Remedy for Type 1 Diabetes
    Rao, Deepthi
    Aldasouqi, Saleh
    Ojha, Mamata
    Tikaria, Richa
    Burns, Tiffany
    ENDOCRINE REVIEWS, 2014, 35 (03)
  • [7] Number of islet β cells better predicts sustained insulin-independence than number of islet equivalents (IE) transplanted in type 1 diabetic patients
    Zhang, HJ
    Ansite, J
    Ihm, SH
    Oberbroeckling, J
    Friberg, A
    Hering, BJ
    AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 : 376 - 376
  • [8] Encapsulated stem cell-derived β cells exert glucose control in patients with type 1 diabetes
    Keymeulen, Bart
    De Groot, Kaat
    Jacobs-Tulleneers-Thevissen, Daniel
    Thompson, David M.
    Bellin, Melena D.
    Kroon, Evert J.
    Daniels, Mark
    Wang, Richard
    Jaiman, Manasi
    Kieffer, Timothy J.
    Foyt, Howard L.
    Pipeleers, Daniel
    NATURE BIOTECHNOLOGY, 2024, 42 (10) : 1507 - +
  • [9] Imeglimin increases glucose-dependent insulin secretion and improves β-cell function in patients with type 2 diabetes
    Pacini, G.
    Mari, A.
    Fouqueray, P.
    Bolze, S.
    Roden, M.
    DIABETES OBESITY & METABOLISM, 2015, 17 (06): : 541 - 545
  • [10] The future treatment for type 1 diabetes: Pig islet- or stem cell-derived β cells?
    Naqvi, Raza Ali
    Naqvi, Afsar Raza
    Singh, Amar
    Priyadarshini, Medha
    Balamurugan, Appakalai N. N.
    Layden, Brian T. T.
    FRONTIERS IN ENDOCRINOLOGY, 2023, 13