Astellolides R-W, Drimane-Type Sesquiterpenoids from an Aspergillus parasiticus Strain Associated with an Isopod

被引：7

作者：

Dai, Guangzhi ^{[1
]}

Sun, Jianpeng ^{[1
]}

Peng, Xiaoping ^{[2
]}

Shen, Qiyao ^{[1
]}

Wu, Changzheng ^{[1
]}

Sun, Zhiheng ^{[1
]}

Sui, Haiyan ^{[1
]}

Ren, Xiangmei ^{[1
]}

Zhang, Youming ^{[1
]}

Bian, Xiaoying ^{[1
]}

机构：

[1] Shandong Univ, Helmholtz Int Lab Antiinfect, Helmholtz Inst Biotechnol, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China

[2] Qingdao Univ, Sch Pharm, Dept Nat Med Chem & Pharmacognosy, Qingdao 266071, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2023年 / 86卷 / 07期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

NITROBENZOYL SESQUITERPENOIDS; FUNGUS; PERICONIANONE; SKELETON;

D O I：

10.1021/acs.jnatprod.3c00215

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Sesquiterpenoids with a cage-like multiring frame arerarely foundin nature. Mining of the isopod-derived fungus Aspergillusparasiticus SDU001 by the one strain-many compounds(OSMAC) strategy unexpectedly led to the discovery of fungal drimane-typesesquiterpenoids astellolide R (1), featuring an unusualcage-like 6/6/5/6/5 pentacyclic ring system, astellolide S (2), possessing a rare nicotinic acid building block, and astellolidesT-W (3-6). Their structureswere comprehensively assigned by spectroscopic data analysis, single-crystalX-ray diffraction, and electronic circular dichroism calculations.Furthermore, compounds 3 and 5 exhibitedanti-inflammatory activity by inhibiting the lipopolyssacharide-inducedNO production in RAW264.7 macrophages with IC50 valuesof 6.1 & PLUSMN; 0.8 and 6.8 & PLUSMN; 0.8 & mu;M, respectively. A putativebiosynthetic pathway for 1 is proposed. Our results enlargethe chemical space of the drimane-type sesquiterpenoids generatedfrom endophytic fungi.

引用

页码：1746 / 1753

页数：8

共 27 条

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