Five new verrucosidin derivatives from Penicillium polonicum, a deep-sea cold-seep sediment isolated fungus

被引：5
|
作者：
Li, Yan-He [1 ,2 ,3 ,4 ]
Yang, Sui-Qun [1 ,2 ,3 ]
Li, Xiao-Ming [1 ,2 ,3 ]
Li, Xin [1 ,2 ,3 ]
Wang, Bin-Gui [1 ,2 ,3 ,4 ,5 ]
Li, Honglei [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, CAS, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
[2] Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
[4] Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
[5] Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
来源：
FITOTERAPIA | 2023年 / 165卷
基金：
中国国家自然科学基金;
关键词：
Verrucosidin derivatives; Penicillium polonicum; Cold-seep-derived fungus;
D O I：
10.1016/j.fitote.2022.105387
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new verrucosidin derivatives, poloncosidins G-K (1-5), were isolated from the deep sea cold-seep sediment-derived fungus Penicillium polonicum CS-252. Their planar structures were elucidated by discreet analysis of the NMR spectroscopic and HRESIMS spectrometric data. The absolute configurations of compounds 1-5 were deduced from the combination of the modified Mosher's method and quantum chemical calculations of their ECD and NMR (with DP4+ probability analysis) data. The antimicrobial activities against several human-and aquatic-pathogenic bacteria of all the isolated compounds were evaluated and the structure-bioactivity relationship was briefly discussed.
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收藏
页数：7
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