Five new verrucosidin derivatives from Penicillium polonicum, a deep-sea cold-seep sediment isolated fungus

被引：5

作者：

Li, Yan-He ^{[1
,2
,3
,4
]}

Yang, Sui-Qun ^{[1
,2
,3
]}

Li, Xiao-Ming ^{[1
,2
,3
]}

Li, Xin ^{[1
,2
,3
]}

Wang, Bin-Gui ^{[1
,2
,3
,4
,5
]}

Li, Honglei ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, CAS, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China

[3] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China

[4] Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China

[5] Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China

来源：

FITOTERAPIA | 2023年 / 165卷

基金：

中国国家自然科学基金;

关键词：

Verrucosidin derivatives; Penicillium polonicum; Cold-seep-derived fungus;

D O I：

10.1016/j.fitote.2022.105387

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new verrucosidin derivatives, poloncosidins G-K (1-5), were isolated from the deep sea cold-seep sediment-derived fungus Penicillium polonicum CS-252. Their planar structures were elucidated by discreet analysis of the NMR spectroscopic and HRESIMS spectrometric data. The absolute configurations of compounds 1-5 were deduced from the combination of the modified Mosher's method and quantum chemical calculations of their ECD and NMR (with DP4+ probability analysis) data. The antimicrobial activities against several human-and aquatic-pathogenic bacteria of all the isolated compounds were evaluated and the structure-bioactivity relationship was briefly discussed.

引用

页数：7

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