Characterization, cytotoxicity, and antibacterial activity of paeoniflorin-loaded mesoporous silica oxide nanoparticles

被引：4
|
作者：
Jin, Yingshan [1 ]
Lu, Yuting [1 ]
Sathiyaseelan, Anbazhagan [2 ]
Saravanakumar, Kandasamy [2 ]
Zhang, Xin [1 ,2 ]
Wang, Myeong-Hyeon [1 ,2 ]
机构：
[1] Yangzhou Univ, Coll Biosci & Biotechnol, Jiangsu Key Lab Zoonosis, Yangzhou 225009, Peoples R China
[2] Kangwon Natl Univ, Dept Biohlth Convergence, Chunchon 24341, South Korea
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2023年 / 84卷
基金：
新加坡国家研究基金会;
关键词：
Silica nanoparticles; Paeoniflorin; Antibacterial activity; Toxicity;
D O I：
10.1016/j.jddst.2023.104551
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Multidrug-resistant (MDR) pathogens are emerging as a major health and safety concern worldwide. Nanomaterials and phyto-compounds are become novel antibacterial agents to target MDR pathogens. To increase the efficacy of phyto-compound in the treatment of MDR bacteria, the present work aimed to develop and characterize the paeoniflorin (Pae) loaded silica oxide nanoparticles (Pae-SiO2 NPs). The loading of the Pae on SiO2 NPs and the crystallinity of Pae-SiO2 NPs were determined by FTIR and XRD analysis. The Pae-SiO2 NPs exhibited an average hydrodynamic size of 226 +/- 7.79 d. nm and a zeta potential of 28.4 +/- 4.59 mV. Furthermore, Pae-SiO2 NPs showed a strong antibacterial effect on Staphylococcus aureus and Bacillus cereus. In addition, Pae-SiO2 NPs showed lowest cytotoxicity and hemolysis in human embryonic kidney 293 cells (HEK 293) and red blood cells (RBC), respectively. Overall, the present results revealed that the Pae-SiO2 NPs exhibited a higher antibacterial activity with lesser toxicity to HEK 293 cells and RBC.
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页数：9
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