Small non-coding RNAs (sncRNA) are involved in many steps of the gene expression cascade and regulate processing and expression of mRNAs by the formation of ribonucleoprotein complexes (RNP) such as the RNA-induced silencing complex (RISC). By analyzing small RNA Seq data sets, we identified a sncRNA annotated as piR-hsa-1254, which is likely derived from the 3'-end of 7SL RNA2 (RN7SL2), herein referred to as snc7SL RNA. The 7SL RNA is an abundant long non-coding RNA polymerase III transcript and serves as structural component of the cytoplasmic signal recognition particle (SRP). To evaluate a potential functional role of snc7SL RNA, we aimed to define its cellular localization by live cell imaging. Therefore, a Molecular Beacon (MB)-based method was established to compare the subcellular localization of snc7SL RNA with its precursor 7SL RNA. We designed and characterized several MBs in vitro and tested those by live cell fluorescence microscopy. Using a multiplex approach, we show that 7SL RNA localizes mainly to the endoplasmic reticulum (ER), as expected for the SRP, whereas snc7SL RNA predominately localizes to the nucleus. This finding suggests a fundamentally different function of 7SL RNA and its derivate snc7SL RNA.
机构:
Fdn IRCCS SDN, Naples, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Cordella, Angela
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Rinaldi, Antonio
Bruno, Giuseppina
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Bruno, Giuseppina
Alexandrova, Elena
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Univ Salerno, Genomix4Life Srl, Spin Off Lab Mol Med & Genom, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Alexandrova, Elena
Saggese, Pasquale
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Saggese, Pasquale
Nassa, Giovanni
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Nassa, Giovanni
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Giurato, Giorgio
Tarallo, Roberta
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Tarallo, Roberta
Marchese, Giovanna
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Univ Salerno, Genomix4Life Srl, Spin Off Lab Mol Med & Genom, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Marchese, Giovanna
Rizzo, Francesca
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Rizzo, Francesca
Stellato, Claudia
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Stellato, Claudia
Biancardi, Rossella
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Univ Salerno Hosp, Dept Med & Surg, SS Giovanni di Dio & Ruggi dAragona Sch Med Saler, Salerno, Italy
Univ Salerno Hosp, Div Obstet & Gynecol, SS Giovanni di Dio & Ruggi dAragona Sch Med Saler, Salerno, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Biancardi, Rossella
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Troisi, Jacopo
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Sardo, Attilio Di Spiezio
Zullo, Fulvio
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Univ Naples Federico II, Dept Gynecol & Obstet & Pathophysiol Human Reprod, Naples, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Zullo, Fulvio
Weisz, Alessandro
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Univ Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
Univ Salerno Hosp, Div Mol Pathol & Med Genom, SS Giovanni di Dio & Ruggi dAragona Sch Med Saler, Salerno, ItalyUniv Salerno, Lab Mol Med & Genom, Dept Med & Surg, I-84081 Baronissi, Italy
机构:
Kings Coll London, British Heart Fdn Ctr Res Excellence, James Black Ctr, Sch Cardiovasc & Metab Med & Sci, 125 Coldharbour Lane, London SE5 9NU, EnglandKings Coll London, British Heart Fdn Ctr Res Excellence, James Black Ctr, Sch Cardiovasc & Metab Med & Sci, 125 Coldharbour Lane, London SE5 9NU, England
Shah, Ajay M.
Giacca, Mauro
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Kings Coll London, British Heart Fdn Ctr Res Excellence, James Black Ctr, Sch Cardiovasc & Metab Med & Sci, 125 Coldharbour Lane, London SE5 9NU, EnglandKings Coll London, British Heart Fdn Ctr Res Excellence, James Black Ctr, Sch Cardiovasc & Metab Med & Sci, 125 Coldharbour Lane, London SE5 9NU, England
机构:
Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Inst Clin Pharm, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Tang, Bing-Jie
Sun, Bao
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Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Inst Clin Pharm, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Sun, Bao
Chen, Lei
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Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Inst Clin Pharm, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Chen, Lei
Xiao, Jie
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Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Inst Clin Pharm, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Xiao, Jie
Huang, Shu-Ting
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Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Inst Clin Pharm, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Huang, Shu-Ting
Xu, Ping
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Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
Cent South Univ, Inst Clin Pharm, Changsha, Peoples R ChinaCent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Peoples R China
机构:
Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Crit Kidney Dis Res Ctr Cent South Univ, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Li, Dan
Xie, Xian
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Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Crit Kidney Dis Res Ctr Cent South Univ, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Xie, Xian
Yin, Ni
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Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Crit Kidney Dis Res Ctr Cent South Univ, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Yin, Ni
Wu, Xueqin
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Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Crit Kidney Dis Res Ctr Cent South Univ, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Wu, Xueqin
Yi, Bin
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机构:
Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Crit Kidney Dis Res Ctr Cent South Univ, Changsha, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Yi, Bin
Zhang, Hao
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机构:
Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China
Crit Kidney Dis Res Ctr Cent South Univ, Changsha, Hunan, Peoples R China
Cent South Univ, Xiangya Hosp 3, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R ChinaCent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Hunan, Peoples R China