Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer

被引：6
|
作者：
Wolf, Philipp [1 ,2 ]
机构：
[1] Univ Freiburg, Med Ctr, Dept Urol, Freiburg, Germany
[2] Univ Freiburg, Fac Med, Freiburg, Germany
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
bladder cancer; apoptosis; inhibitor of apoptosis proteins; cIAP1; cIAP2; XIAP; Survivin; Livin; EARLY RECURRENCE; PROGNOSTIC-SIGNIFICANCE; URINARY BIOMARKERS; MELANOMA INHIBITOR; LIGASE ACTIVITY; SMAC MIMETICS; IAP PROTEINS; SURVIVIN; EXPRESSION; LIVIN;
D O I：
10.3389/fonc.2023.1124600
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Evasion from apoptosis is a hallmark of cancer. Inhibitor of apoptosis proteins (IAPs) contribute to this hallmark by suppressing the induction of cell death. IAPs were found to be overexpressed in cancerous tissues and to contribute to therapeutic resistance. The present review focuses on the IAP members cIAP1, cIAP2, XIAP, Survivin and Livin and their importance as potential therapeutic targets in bladder cancer.
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页数：8
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