Molecular mechanisms of long noncoding RNAs associated with cervical cancer radiosensitivity

被引：7
|
作者：
Wu, Shuying [1 ]
Zhu, He [1 ]
Wu, Yishi [1 ]
Wang, Cong [1 ]
Duan, Xuefeng [1 ]
Xu, Tianmin [1 ]
机构：
[1] Second Hosp Jilin Univ, Dept Obstet & Gynecol, Changchun, Peoples R China
来源：
FRONTIERS IN GENETICS | 2023年 / 13卷
关键词：
cervical cancer; long noncoding RNA (lncRNA); radiosensitive; DNA damage repair; apoptosis; EPITHELIAL-MESENCHYMAL TRANSITION; STRAND BREAK REPAIR; ATM PROTEIN-KINASE; CELL LUNG-CANCER; ENHANCES RADIOSENSITIVITY; STEMNESS MAINTENANCE; SIGNALING PATHWAY; CARCINOMA-CELLS; SELF-RENEWAL; PROMOTES;
D O I：
10.3389/fgene.2022.1093549
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Despite advances in cervical cancer screening and human papilloma virus (HPV) vaccines, cervical cancer remains a global health burden. The standard treatment of cervical cancer includes surgery, radiation therapy, and chemotherapy. Radiotherapy (RT) is the primary treatment for advanced-stage disease. However, due to radioresistance, most patients in the advanced stage have an adverse outcome. Recent studies have shown that long noncoding RNAs (lncRNAs) participate in the regulation of cancer radiosensitivity by regulating DNA damage repair, apoptosis, cancer stem cells (CSCs), and epithelial-mesenchymal transition (EMT). In this review, we summarize the molecular mechanisms of long noncoding RNAs in cervical cancer and radiosensitivity, hoping to provide a theoretical basis and a new molecular target for the cervical cancer RT in the clinic.
引用
收藏
页数：14
相关论文
共 50 条
  • [31] Molecular mechanisms of circular RNAs, transforming growth factor-β, and long noncoding RNAs in hepatocellular carcinoma
    Shang, Wenkang
    Adzika, Gabriel Komla
    Li, Yujie
    Huang, Qike
    Ding, Ningding
    Chinembiri, Bianca
    Ibn Rashid, Mohammad Sajjad
    Machuki, Jeremiah Ongachwa
    CANCER MEDICINE, 2019, 8 (15): : 6684 - 6699
  • [32] Long noncoding RNAs (lncRNAs) in cervical carcinogenesis: New molecular targets, current prospects
    Tabosa de Carvalho Galvao, Maria Luiza
    Coimbra, Eliane Campos
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2020, 156
  • [33] Long Noncoding RNAs and Circular RNAs in the Metabolic Reprogramming of Lung Cancer: Functions, Mechanisms, and Clinical Potential
    Zhou, Yuhao
    Zhan, Yuan
    Jiang, Weiling
    Liu, Huiguo
    Wei, Shuang
    Oxidative Medicine and Cellular Longevity, 2022, 2022
  • [34] Genetic variations associated with long noncoding RNAs
    Luo, Jianjun
    Chen, Runsheng
    SPOTLIGHT ON CHINA: RNA, 2020, 64 (06): : 867 - 873
  • [35] Long Noncoding RNAs and Circular RNAs in the Metabolic Reprogramming of Lung Cancer: Functions, Mechanisms, and Clinical Potential
    Zhou, Yuhao
    Zhan, Yuan
    Jiang, Weiling
    Liu, Huiguo
    Wei, Shuang
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
  • [36] A four immune-related long noncoding RNAs signature as predictors for cervical cancer
    Min Xu
    Runjie Zhang
    Jin Qiu
    Human Cell, 2022, 35 : 348 - 359
  • [37] Molecular mechanisms underlying actions of certain long noncoding RNAs in Alzheimer's disease
    Ahmadi, Shamseddin
    Zobeiri, Mohammad
    Bradburn, Steven
    METABOLIC BRAIN DISEASE, 2020, 35 (05) : 681 - 693
  • [38] A four immune-related long noncoding RNAs signature as predictors for cervical cancer
    Xu, Min
    Zhang, Runjie
    Qiu, Jin
    HUMAN CELL, 2022, 35 (01) : 348 - 359
  • [39] Molecular mechanisms underlying actions of certain long noncoding RNAs in Alzheimer’s disease
    Shamseddin Ahmadi
    Mohammad Zobeiri
    Steven Bradburn
    Metabolic Brain Disease, 2020, 35 : 681 - 693
  • [40] Technologies to probe functions and mechanisms of long noncoding RNAs
    Chu, Ci
    Spitale, Robert C.
    Chang, Howard Y.
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2015, 22 (01) : 29 - 35
12345