Molecular mechanisms of long noncoding RNAs associated with cervical cancer radiosensitivity

被引：7
|
作者：
Wu, Shuying [1 ]
Zhu, He [1 ]
Wu, Yishi [1 ]
Wang, Cong [1 ]
Duan, Xuefeng [1 ]
Xu, Tianmin [1 ]
机构：
[1] Second Hosp Jilin Univ, Dept Obstet & Gynecol, Changchun, Peoples R China
来源：
FRONTIERS IN GENETICS | 2023年 / 13卷
关键词：
cervical cancer; long noncoding RNA (lncRNA); radiosensitive; DNA damage repair; apoptosis; EPITHELIAL-MESENCHYMAL TRANSITION; STRAND BREAK REPAIR; ATM PROTEIN-KINASE; CELL LUNG-CANCER; ENHANCES RADIOSENSITIVITY; STEMNESS MAINTENANCE; SIGNALING PATHWAY; CARCINOMA-CELLS; SELF-RENEWAL; PROMOTES;
D O I：
10.3389/fgene.2022.1093549
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Despite advances in cervical cancer screening and human papilloma virus (HPV) vaccines, cervical cancer remains a global health burden. The standard treatment of cervical cancer includes surgery, radiation therapy, and chemotherapy. Radiotherapy (RT) is the primary treatment for advanced-stage disease. However, due to radioresistance, most patients in the advanced stage have an adverse outcome. Recent studies have shown that long noncoding RNAs (lncRNAs) participate in the regulation of cancer radiosensitivity by regulating DNA damage repair, apoptosis, cancer stem cells (CSCs), and epithelial-mesenchymal transition (EMT). In this review, we summarize the molecular mechanisms of long noncoding RNAs in cervical cancer and radiosensitivity, hoping to provide a theoretical basis and a new molecular target for the cervical cancer RT in the clinic.
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页数：14
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