The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases

被引：11
|
作者：
Liu, Na [1 ,2 ]
Lin, Miao-Miao [1 ,2 ]
Wang, Yan [1 ,2 ]
机构：
[1] Soochow Univ, Dept Pharmacol, Coll Pharmaceut Sci, Suzhou Key Lab Aging & Nervous Dis, Suzhou, Jiangsu, Peoples R China
[2] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Jiangsu, Peoples R China
来源：
MOLECULAR NEUROBIOLOGY | 2023年 / 60卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Neurodegenerative diseases; Ubiquitination; E3 ubiquitin ligases; Deubiquitinating enzymes; ALPHA-SYNUCLEIN TOXICITY; AMYOTROPHIC-LATERAL-SCLEROSIS; MUTANT HUNTINGTIN TOXICITY; PROTEIN-QUALITY CONTROL; C-TERMINAL HYDROLASE; PARKINSONS-DISEASE; DEUBIQUITINATING ENZYME; UBIQUITIN LIGASE; PROTEASOME ACTIVITY; SIGNALING PATHWAY;
D O I：
10.1007/s12035-022-03063-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes.
引用
收藏
页码：247 / 263
页数：17
相关论文
共 50 条
  • [21] Functional roles of E3 ubiquitin ligases in prostate cancer
    Yiting Zhao
    Jinyun Li
    Jun Chen
    Meng Ye
    Xiaofeng Jin
    Journal of Molecular Medicine, 2022, 100 : 1125 - 1144
  • [22] E3 ubiquitin ligases as novel targets for inflammatory diseases
    Goru, Santosh Kumar
    Pandey, Anuradha
    Gaikwad, Anil Bhanudas
    PHARMACOLOGICAL RESEARCH, 2016, 106 : 1 - 9
  • [23] The E3 ubiquitin ligases regulate inflammation in cardiovascular diseases
    Chen, Xiao
    Ma, Jia
    Wang, Zhi-wei
    Wang, Zhiting
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2024, 154 : 167 - 174
  • [24] E3 ubiquitin ligases
    Ardley, HC
    Robinson, PA
    ESSAYS IN BIOCHEMISTRY, VOL 41: THE UBIQUITIN-PROTEASOME SYSTEM, 2005, 41 : 15 - 30
  • [25] A design principle underlying the paradoxical roles of E3 ubiquitin ligases
    Daewon Lee
    Minjin Kim
    Kwang-Hyun Cho
    Scientific Reports, 4
  • [26] A design principle underlying the paradoxical roles of E3 ubiquitin ligases
    Lee, Daewon
    Kim, Minjin
    Cho, Kwang-Hyun
    SCIENTIFIC REPORTS, 2014, 4
  • [27] Roles of E3 Ubiquitin Ligases in Plant Responses to Abiotic Stresses
    Wang, Shuang
    Lv, Xiaoyan
    Zhang, Jialin
    Chen, Daniel
    Chen, Sixue
    Fan, Guoquan
    Ma, Chunquan
    Wang, Yuguang
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (04)
  • [28] The roles of E3 ubiquitin ligases in cancer progression and targeted therapy
    Sampson, Chibuzo
    Wang, Qiuping
    Otkur, Wuxiyar
    Zhao, Haifeng
    Lu, Yun
    Liu, Xiaolong
    Piao, Hai-long
    CLINICAL AND TRANSLATIONAL MEDICINE, 2023, 13 (03):
  • [29] Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity
    Humphries, Fiachra
    Moynagh, Paul N.
    IMMUNOLOGICAL REVIEWS, 2015, 266 (01) : 93 - 108
  • [30] Emerging Roles of the TRIM E3 Ubiquitin Ligases MID1 and MID2 in Cytokinesis
    Zanchetta, Melania Eva
    Meroni, Germana
    FRONTIERS IN PHYSIOLOGY, 2019, 10
12345