Plasma biomarkers for brain injury in extracorporeal membrane oxygenation

被引：0
|
作者：
Kapoor, Shrey [1 ,2 ,3 ,4 ]
Kolchinski, Anna [1 ,2 ,3 ,4 ]
Gusdon, Aaron M. [5 ]
Premraj, Lavienraj [6 ,7 ]
Cho, Sung-Min [1 ,2 ,3 ,4 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Div Neurosci Crit Care & Cardiac Surg, Baltimore, MD USA
[2] Johns Hopkins Univ, Sch Med, Dept Surg, Div Neurosci Crit Care & Cardiac Surg, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Anesthesiol, Div Neurosci Crit Care & Cardiac Surg, Baltimore, MD USA
[4] Johns Hopkins Univ, Sch Med, Dept Crit Care Med, Div Neurosci Crit Care & Cardiac Surg, Baltimore, MD USA
[5] Univ Texas Hlth Sci Ctr Houston, McGovern Sch Med, Div Neurocrit Care, Dept Neurosurg, Houston, TX USA
[6] Griffith Univ, Sch Med, Griffith, NSW, Australia
[7] Prince Charles Hosp, Crit Care Res Grp, Chermside, Qld, Australia
来源：
ACUTE AND CRITICAL CARE | 2023年 / 38卷 / 04期
关键词：
acute brain injury; biomarkers; extracorporeal membrane oxygenation; FIBRILLARY ACIDIC PROTEIN; CELL-FREE DNA; MITOCHONDRIAL-DNA; ONCOSTATIN M; SERUM; GFAP; TAU; PREDICT; DAMAGE; S100B;
D O I：
10.4266/acc.2023.01368
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with refractory cardiorespiratory failure. Despite its benefits, ECMO carries a significant risk of neurological complications, including acute brain injury (ABI). Although standardized neuromonitoring and neurological care have been shown to improve early detection of ABI, the inability to perform neuroimaging in a timely manner is a major limitation in the accurate diagnosis of neurological complications. Therefore, blood-based biomarkers capable of detecting ongoing brain injury at the bedside are of great clinical significance. This review aims to provide a concise review of the current literature on plasma biomarkers for ABI in patients on ECMO support.
引用
收藏
页码：389 / 398
页数：10
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