NMDA Inhibitors: A Potential Contrivance to Assist in Management of Alzheimer's Disease

被引：6

作者：

Painuli, Sakshi ^{[1
,2
]}

Semwal, Prabhakar ^{[2
]}

Zam, Wissam ^{[3
]}

Taheri, Yasaman ^{[4
]}

Ezzat, Shahira M. ^{[5
,6
]}

Zuo, Peijun ^{[7
]}

Li, Liping ^{[7
]}

Kumar, Dileep ^{[8
]}

Sharifi-Rad, Javad ^{[9
,13
]}

Cruz-Martins, Natalia ^{[10
,11
,12
,14
]}

机构：

[1] Himalayan Environm Studies & Conservat Org HESCO, Dehra Dun 248006, India

[2] Graphic Era Deemed be Univ, Dept Life Sci, Dehra Dun 248002, India

[3] Tartous Univ, Fac Pharm, Dept Analyt & Food Chem, Tartous, Syria

[4] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran

[5] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt

[6] October Univ Modern Sci & Arts MSA, Fac Pharm, Dept Pharmacognosy, Giza 12451, Egypt

[7] Shantou Univ, Sch Publ Hlth, Shantou, Guangdong, Peoples R China

[8] Bharati Vidyapeeth Deemed be Univ, Poona Coll Pharm, Pune 411038, Maharashtra, India

[9] Univ Azuay, Fac Med, Cuenca, Ecuador

[10] Univ Porto, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[11] Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal

[12] Inst Res & Adv Training Hlth Sci & Technol CESPU, Rua Cent Gandra 1317, P-4585116 Gandra, Portugal

[13] Univ Azuay, Fac Med, Cuenca, Ecuador

[14] Univ Porto, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2023年 / 26卷 / 12期

关键词：

Alzheimer's disease; neurodegeneration; N-methyl D-aspartate (NMDA) receptors; precision medicine; NMDA; dimensia; METHYL-D-ASPARTATE; AMYLOID PRECURSOR PROTEIN; LONG-TERM-POTENTIATION; A-BETA ACCUMULATION; APOLIPOPROTEIN-E; SYNAPTIC PLASTICITY; MODERATELY SEVERE; TYROSINE PHOSPHORYLATION; RECEPTOR ANTAGONIST; GLUTAMATE TOXICITY;

D O I：

10.2174/1386207325666220428112541

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is an increasingly common neurodegenerative disease that attracts the attention of researchers and medical community in order to develop new, safe and more effective drugs. Currently available drugs could only slow the AD progression and relieve the symptoms, in addition to being linked to moderate-to-severe side effects. N-methyl D-aspartate (NMDA) receptors antagonists were reported to have the ability to block the glutamate-mediated excitotoxic activity being good therapeutic targets for several neurodegenerative diseases, including AD. Based on data obtained so far, this review provides an overview over the use of NMDA antagonists for AD treatment, starting with a key emphasis on present features and future aspects regarding the use of NMDA antagonists for AD, and lastly a key focus is also given on its use in precision medicine.

引用

页码：2099 / 2112

页数：14

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