Circulating retinol and 25(OH)D contents and their association with symptoms in children with chronic tic disorders

被引:1
|
作者
Wang, Cheng-Xin [1 ,3 ]
Wang, Bing [1 ]
Sun, Jian-Jian [1 ]
Xiao, Chun-Ying [1 ]
Ma, Huan [1 ]
Jia, Fei-Yong [1 ]
Li, Hong-Hua [1 ,2 ]
机构
[1] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun 130021, Jilin, Peoples R China
[2] Jilin Univ, Sch Publ Hlth, Changchun, Jilin, Peoples R China
[3] First Hosp Jilin Univ, Dept Lab Med, Changchun 130021, Peoples R China
关键词
Chronic tic disorders; Vitamin A; Vitamin D; Attention deficit hyperactivity disorder; Children; NARRATIVE EXPOSURE THERAPY; PSYCHOLOGICAL ADJUSTMENT; TERRORIST ATTACK; MENTAL-HEALTH; SOLDIERS; EXPERIENCES; ABDUCTION; HOSTAGE;
D O I
10.1007/s00787-023-02226-4
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
The present study measured serum levels of vitamin A (VA) and vitamin D (VD) in children with chronic tic disorders (CTD) and investigated their potential association with CTD and comorbidity of attention deficit hyperactivity disorder (ADHD) and the association of their co-insufficiencies or deficiencies with CTD symptoms. A total of 176 children (131 boys and 45 girls, median age of 9 years) with CTD were recruited as the CTD group. During the same period, 154 healthy children were selected as the healthy control (HC) cohort. Circulating retinol and 25-hydroxyvitamin D (25[OH]D) levels were measured for all participants using high-performance liquid chromatography (HPLC) and tandem mass spectrometry. The Yale Global Tic Severity Scale (YGTSS) was employed for the assessment of tic status and CTD impairment. The Swanson, Nolan, and Pelham Rating Scale (SNAP-IV) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) were used to evaluate comorbidity symptoms. CTD pediatric participants exhibited markedly diminished circulating retinol and 25(OH)D levels compared to HCs. Moreover, VA and VD deficiencies and their co-insufficiencies/deficiencies were more prevalent in CTD participants than HCs. Circulating 25(OH)D levels were inversely proportional to the YGTSS motor tic scores. YGTSS scores in CTD children with only VA or VD insufficiency or deficiency or with VA and VD co-insufficiency/deficiency did not differ from those in CTD children with normal VA and VD. CTD children with comorbid ADHD displayed reduced circulating retinol and 25(OH)D concentrations and elevated prevalence of VD deficiency compared to CTD participants without comorbid ADHD. Lower serum retinol content was intricately linked to the presence of elevated CTD and comorbid ADHD. VA and VD deficiencies and their co-insufficiencies/deficiencies were markedly enhanced in CTD pediatric participants compared to HCs. Lower VA concentration was linked to the presence of enhanced CTD and comorbid ADHD. Therefore, children with CTD, especially with comorbid ADHD, may be at a higher risk of VA or VD deficiency, which may prompt the clinicians to consider whether blood tests for VA and VD in CTD children would be helpful for clinical care.
引用
收藏
页码:1017 / 1028
页数:12
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