Aryldiazonium Salt-Triggered [2+2+1] Heteroannulation of Indoles by an Arylhydrazone Radical-Relayed 1,5-Hydrogen Atom Transfer

被引：4

作者：

Ouyang, Jun-Yao ^{[1
]}

Shen, Fang-Fang ^{[1
]}

Zhao, Han-Qing ^{[1
]}

Chen, Jia-Jie ^{[1
]}

Wen, Zhu-Dong ^{[1
]}

Jiang, Hui-Min ^{[1
]}

Qin, Jing-Hao ^{[1
]}

Sun, Qing ^{[1
]}

Li, Jin-Heng ^{[2
,3
,4
]}

Ouyang, Xuan-Hui ^{[1
]}

机构：

[1] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Control, Nanchang 330063, Peoples R China

[2] Qingdao Univ Sci, Coll Chem, State Key Lab Base Ecochem Engn, Qingdao 266042, Peoples R China

[3] Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

[4] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 35期

关键词：

C-H FUNCTIONALIZATION; LIGHT; DERIVATIVES; GENERATION;

D O I：

10.1021/acs.orglett.3c02373

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented three-component [2 + 2 + 1] annulation cascade of indoles with aryldiazonium salts and polyhalomethanes or acetone is presented by dual hydrogen atom transfer (HAT) and C-H functionalization. By employing readily accessible aryldiazonium salts as the radical initiators and electrophiles and polyhalomethanes and acetone as the C1 units, this method unprecedentedly constructs a pyrazole ring on an indole ring skeleton through the formation of two C-N bonds and a C-C bond in a single reaction.

引用

页码：6549 / 6554

页数：6

共 46 条

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