Various strategies for developing APOBEC3G protectors to circumvent human immunodeficiency virus type 1

被引：0
|
作者：
Bao, Qiqi [1 ,2 ]
Zhou, Jinming [1 ,2 ]
机构：
[1] Zhejiang Normal Univ, Dept Chem, Key Lab Minist Educ Adv Catalysis Mat, 688 Yingbin Rd, Jinhua 321004, Peoples R China
[2] Zhejiang Normal Univ, Coll Chem & Life Sci, Drug Dev & Innovat Ctr, 688 Yingbin Rd, Jinhua 321004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 250卷
关键词：
HIV-1; REVERSE-TRANSCRIPTASE; SMALL-MOLECULE INHIBITION; CYTIDINE DEAMINASE; MESSENGER-RNA; ANTIRETROVIRAL THERAPY; ANTIVIRAL ACTIVITY; CBF-BETA; INDEPENDENT RESTRICTION; ENZYME APOBEC3G; INNATE IMMUNITY;
D O I：
10.1016/j.ejmech.2023.115188
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Host restriction factor APOBEC3G (A3G) efficiently restricts Vif-deficient HIV-1 by being packaged with progeny virions and causing the G to A mutation during HIV-1 viral DNA synthesis as the progeny virus infects new cells. HIV-1 expresses Vif protein to resist the activity of A3G by mediating A3G degradation. This process requires the self-association of Vif in concert with A3G proteins, protein chaperones, and factors of the ubiquitination ma-chinery, which are potential targets to discover novel anti-HIV drugs. This review will describe compounds that have been reported so far to inhibit viral replication of HIV-1 by protecting A3G from Vif-mediated degradation.
引用
收藏
页数：14
相关论文
共 50 条
  • [21] Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation
    Luo, Kun
    Wang, Tao
    Liu, Bindong
    Tian, Chunjuan
    Xiao, Zuoxiang
    Kappes, John
    Yu, Xiao-Fang
    JOURNAL OF VIROLOGY, 2007, 81 (13) : 7238 - 7248
  • [22] APOBEC3G expression and hypermutation are inversely associated with human immunodeficiency virus type 1 (HIV-1) burden in vivo
    Kourteva, Yordanka
    De Pasquale, MariaPia
    Allos, Tara
    McMunn, Chara
    D'Aquila, Richard T.
    VIROLOGY, 2012, 430 (01) : 1 - 9
  • [23] Influence of primate lentiviral vif and proteasome inhibitors on human immunodeficiency virus type 1 virion packaging of APOBEC3G
    Liu, BD
    Yu, XH
    Luo, K
    Yu, YK
    Yu, XF
    JOURNAL OF VIROLOGY, 2004, 78 (04) : 2072 - 2081
  • [24] APOBEC3G targets human T-cell leukemia virus type 1
    Amane Sasada
    Akifumi Takaori-Kondo
    Kotaro Shirakawa
    Masayuki Kobayashi
    Aierkin Abudu
    Masakatsu Hishizawa
    Kazunori Imada
    Yuetsu Tanaka
    Takashi Uchiyama
    Retrovirology, 2
  • [25] APOBEC3G targets human T-cell leukemia virus type 1
    Sasada, A
    Takaori-Kondo, A
    Shirakawa, K
    Kobayashi, M
    Abudu, A
    Hishizawa, M
    Imada, K
    Tanaka, Y
    Uchiyama, T
    RETROVIROLOGY, 2005, 2 (1)
  • [26] Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells
    Kao S.
    Miyagi E.
    Khan M.A.
    Takeuchi H.
    Opi S.
    Goila-Gaur R.
    Strebel K.
    Retrovirology, 1 (1)
  • [27] APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells
    Wang, Feng-xiang
    Huang, Jialing
    Zhang, Hangxiang
    Ma, Xinliang
    Zhang, Hui
    JOURNAL OF GENERAL VIROLOGY, 2008, 89 : 722 - 730
  • [28] The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA
    Guo, Fei
    Cen, Shan
    Niu, Meijuan
    Yang, Yiliang
    Gorelick, Robert J.
    Kleiman, Lawrence
    JOURNAL OF VIROLOGY, 2007, 81 (20) : 11322 - 11331
  • [29] Exosomes Packaging APOBEC3G Confer Human Immunodeficiency Virus Resistance to Recipient Cells
    Khatua, Atanu K.
    Taylor, Harry E.
    Hildreth, James E. K.
    Popik, Waldemar
    JOURNAL OF VIROLOGY, 2009, 83 (02) : 512 - 521
  • [30] Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation
    Pace, Craig
    Keller, Jean
    Nolan, David
    James, Ian
    Gaudieri, Silvana
    Moore, Corey
    Mallal, Simon
    JOURNAL OF VIROLOGY, 2006, 80 (18) : 9259 - 9269
12345