Synthesis and Biological Evaluation of New Nitroimidazole Derivatives as Anti-Helicobacter pylori Agents Against Metronidazole-Resistant Strains

被引：1
|
作者：
Bayati, Zahra [1 ]
Amidi, Salimeh [1 ]
Shahabimehr, Mahnaz [2 ]
Alebouyeh, Masoud [3 ]
Mahboubi, Arash [4 ]
Tabatabai, Sayyed Abbas [1 ,5 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Pharmaceut Chem, Sch Pharm, Tehran, Iran
[2] Islamic Azad Univ, Pharmaceut Sci Fac, Dept Biol, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Food Safety Res Ctr, Sch Pharm, Dept Pharmaceut, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran
来源：
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2023年 / 22卷 / 01期
关键词：
Nitroimidazole Derivatives; Metronidazole Resistance; Helicobacter pylori; Synthesis; DESIGN; ERADICATION; INHIBITORS; DIVERSITY;
D O I：
10.5812/ijpr-137969
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since several Helicobacter pylori strains have become resistant to metronidazole, new nitroimidazole derivatives based on metronidazole were designed and synthesized with different substituents on imidazole nitrogen. The activity of the synthesized compounds was evaluated against 20 clinically isolated metronidazole-resistant H. pylori strains. Some synthesized compounds were effective against those metronidazole-resistant H. pylori strains. Three compounds exhibited the most potent inhibitory activities (MIC50 = 8 mu g/mL and MIC90 =16 mu g/mL).
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页数：8
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