Synthesis and Biological Evaluation of New Nitroimidazole Derivatives as Anti-Helicobacter pylori Agents Against Metronidazole-Resistant Strains

被引：1
|
作者：
Bayati, Zahra [1 ]
Amidi, Salimeh [1 ]
Shahabimehr, Mahnaz [2 ]
Alebouyeh, Masoud [3 ]
Mahboubi, Arash [4 ]
Tabatabai, Sayyed Abbas [1 ,5 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Pharmaceut Chem, Sch Pharm, Tehran, Iran
[2] Islamic Azad Univ, Pharmaceut Sci Fac, Dept Biol, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Food Safety Res Ctr, Sch Pharm, Dept Pharmaceut, Tehran, Iran
[5] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran
来源：
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2023年 / 22卷 / 01期
关键词：
Nitroimidazole Derivatives; Metronidazole Resistance; Helicobacter pylori; Synthesis; DESIGN; ERADICATION; INHIBITORS; DIVERSITY;
D O I：
10.5812/ijpr-137969
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since several Helicobacter pylori strains have become resistant to metronidazole, new nitroimidazole derivatives based on metronidazole were designed and synthesized with different substituents on imidazole nitrogen. The activity of the synthesized compounds was evaluated against 20 clinically isolated metronidazole-resistant H. pylori strains. Some synthesized compounds were effective against those metronidazole-resistant H. pylori strains. Three compounds exhibited the most potent inhibitory activities (MIC50 = 8 mu g/mL and MIC90 =16 mu g/mL).
引用
收藏
页数：8
相关论文
共 50 条
  • [1] FAILURE TO ERADICATE HELICOBACTER-PYLORI IN PATIENTS WITH METRONIDAZOLE-RESISTANT STRAINS
    VANZWET, AA
    THIJS, JC
    OOM, JAJ
    HOOGEVEEN, J
    DURINGSHOFF, BL
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1993, 5 (03) : 185 - 186
  • [2] Metronidazole-resistant Helicobacter pylori strains among Saudi patients with dyspepsia
    AlKnawy, BA
    Bilal, NE
    Ahmed, MEBK
    AlWabel, AA
    Foli, AK
    AlHumaidi, MA
    Shatoor, AS
    Mirdad, S
    Abolfotouh, M
    SAUDI MEDICAL JOURNAL, 1997, 18 (03) : 261 - 263
  • [3] Sulforaphane Suppresses Helicobacter pylori Activity and Increases Metronidazole Susceptibility in Metronidazole-Resistant Strains In Vitro
    Kameyama, Mana
    Fukumoto, Atsushi
    Mino, Kazunari
    Yanaka, Akinori
    GASTROENTEROLOGY, 2009, 136 (05) : A339 - A339
  • [4] Appearance of a metronidazole-resistant Helicobacter pylori strain in an infected-ICR-mouse model and difference in eradication of metronidazole-resistant and -sensitive strains
    Matsumoto, S
    Washizuka, Y
    Matsumoto, Y
    Tawara, S
    Ikeda, F
    Yokota, Y
    Karita, M
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (12) : 2602 - 2605
  • [5] IN VITRO ANTIMICROBIAL ACTIVITY OF RIFABUTIN AGAINST METRONIDAZOLE-RESISTANT HELICOBACTER PYLORI ISOLATES
    Siavoshi, F.
    Bolandi, Z.
    Malekzadeh, R.
    Eyvazi, S.
    Honarmand, S.
    HELICOBACTER, 2012, 17 : 107 - 107
  • [6] CLARITHROMYCIN AS AN ALTERNATIVE TO METRONIDAZOLE IN TRIPLE THERAPY OF HELICOBACTER-PYLORI IN PATIENTS HARBORING METRONIDAZOLE-RESISTANT STRAINS
    VANZWET, AA
    THIJS, JC
    GASTROENTEROLOGY, 1994, 106 (04) : A204 - A204
  • [7] KREBS CYCLE AND PYRUVATE OXIDOREDUCTASE ACTIVITIES IN METRONIDAZOLE-RESISTANT STRAINS OF HELICOBACTER-PYLORI
    HOFFMAN, PS
    GOODWIN, A
    JOHNSEN, J
    VANZANTEN, SV
    GASTROENTEROLOGY, 1995, 108 (04) : A835 - A835
  • [8] 5-Nitroimidazole-based 1,3,4-Thiadiazoles: Heterocyclic Analogs of Metronidazole as Anti-Helicobacter pylori Agents
    Moshafi, Mohammad Hassan
    Sorkhi, Maedeh
    Emami, Saeed
    Nakhjiri, Maryam
    Yahya-Meymandi, Azadeh
    Negahbani, Amir Soheil
    Siavoshi, Farideh
    Omrani, Maryam
    Alipour, Eskandar
    Vosooghi, Mohsen
    Shafiee, Abbas
    Foroumadi, Alireza
    ARCHIV DER PHARMAZIE, 2011, 344 (03) : 178 - 183
  • [9] Study of the combination of ranitidine bismuth citrate and metronidazole against metronidazole-resistant Helicobacter pylori clinical isolates
    López-Brea, M
    Domingo, D
    Sánchez, I
    Prieto, N
    Alarcón, T
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (03) : 309 - 314
  • [10] A review on the structures and biological activities of anti-Helicobacter pylori agents
    Ghobadi, Elham
    Ghanbarimasir, Zahra
    Emami, Saeed
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 223
12345