Effectiveness of Injectable Platelet Rich Fibrin with Demineralised Freeze Dried Bone Allograft in Class II Furcation Defects: Protocol for a Randomised Clinical Trial

Introduction: In cases of substantial furcation involvement, non surgical mechanical debridement results in disease progression. Surgery allows for root debridement, osseous recontouring, odontoblasts, and periodontal regeneration while maintaining periodontal attachment, to stop the disease process. The current study evaluates whether combining injectable-Platelet Rich Fibrin (i-PRF) mixed with Demineralised Freeze-Dried Bone Allograft (DFDBA) for treating Class-II furcation diseases is successful.Need for the Study: In comparison to 'Open Flap Debridement' (OFD) alone, certain studies have shown that DFDBA results in a considerable and persistent increase in periodontal regeneration. The current study evaluates whether combining i-PRF mixed with DFDBA for treating Class-II-furcation diseases is successful or not.Aim: To compare evaluation of i-PRF with DFDBA compared to DFDBA alone in the treatment of the Class-II furcation defects-a randomised controlled clinical trial.Materials and Methods: The current investigation will be a randomised, clinical trial. Twenty-four patients of 'Class-II furcation' diseases including the buccal/lingual sides will be chosen. By the completion of the first therapy and before the beginning of surgery, the chosen defects will be going randomly allotted to group A and group B equally, using a computer-generated randomisation process employing a randomised table. group A will operate with both i-PRF and DFDBA, whereas group B here will only be given DFDBA. To estimate outcomes, a re-evaluation will be done at six and nine months after starting therapy.