Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancers

被引:4
|
作者
Wang, Xiaoxiao [1 ]
Zhang, Chao [1 ]
Song, Huangqin [1 ]
Yuan, Junlong [1 ]
Zhang, Xiaomin [1 ]
Yuan, Yiran [1 ]
Zhang, Lei [2 ,3 ]
He, Jiefeng [1 ,2 ]
机构
[1] Shanxi Med Univ, Shanxi Acad Med Sci, Shanxi Bethune Hosp, Tongji Shanxi Hosp,Hosp 3, Taiyuan, Peoples R China
[2] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Dept Hepatobiliary Surg,Hosp 3, Taiyuan, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Hepatopancreato Biliary Surg, Tongji Med Coll,Hepat Surg Ctr, Wuhan, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
基金
中国国家自然科学基金;
关键词
actin cytoskeleton; LIMA1; cells migration and metastatic; EMT; angiogenesis; cancer progression; EPITHELIAL PROTEIN LOST; REGULATES ACTIN ORGANIZATION; NEOPLASM EPLIN; ENDOTHELIAL-CELLS; CROSS-LINKING; DYNAMICS; GROWTH; ALPHA; ADHESION; OSTEOSARCOMA;
D O I
10.3389/fonc.2023.1115943
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Actin is the most abundant and highly conserved cytoskeletal protein present in all eukaryotic cells. Remodeling of the actin cytoskeleton is controlled by a variety of actin-binding proteins that are extensively involved in biological processes such as cell motility and maintenance of cell shape. LIM domain and actin-binding protein 1 (LIMA1), as an important actin cytoskeletal regulator, was initially thought to be a tumor suppressor frequently downregulated in epithelial tumors. Importantly, the deficiency of LIMA1 may be responsible for dysregulated cytoskeletal dynamics, altered cell motility and disrupted cell-cell adhesion, which promote tumor proliferation, invasion and migration. As research progresses, the roles of LIMA1 extend from cytoskeletal dynamics and cell motility to cell division, gene regulation, apical extrusion, angiogenesis, cellular metabolism and lipid metabolism. However, the expression of LIMA1 in malignant tumors and its mechanism of action have not yet been elucidated, and many problems and challenges remain to be addressed. Therefore, this review systematically describes the structure and biological functions of LIMA1 and explores its expression and regulatory mechanism in malignant tumors, and further discusses its clinical value and therapeutic prospects.
引用
收藏
页数:17
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