Spatiotemporal Distribution and Function of Mitochondria in Oocytes

被引：4

作者：

Kang, Xin ^{[1
,2
,3
,4
,5
]}

Yan, Liying ^{[1
,2
]}

Wang, Jing ^{[1
,2
,3
,4
,5
]}

机构：

[1] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

[2] Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China

[3] Peking Univ, Key Lab Assisted Reprod, Minist Educ, Beijing 100191, Peoples R China

[4] Beijing Key Lab Reprod Endocrinol & Assisted Repro, Beijing 100191, Peoples R China

[5] Chinese Acad Med Sci, Res Units Comprehens Diag & Treatment Oocyte Matur, Beijing 100191, Peoples R China

来源：

REPRODUCTIVE SCIENCES | 2024年 / 31卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Mitochondria; Oocyte maturation; Mitochondria distribution; mtDNA copy number; Transcriptome; ENDOPLASMIC-RETICULUM; DNA HETEROPLASMY; MOUSE OOCYTE; IN-VITRO; MATURATION; DYNAMICS; SEQUENCE; ULTRASTRUCTURE; MECHANISMS; CRISTAE;

D O I：

10.1007/s43032-023-01331-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Mitochondria are energy provider organelles in eukaryotic cells that contain their own specific genome. This review addresses structural and functional properties of mitochondria, focusing on recent discoveries about the changes in quality and number of mitochondria per cell during oocyte development. We highlight how oocyte mitochondria exhibit stage-specific morphology and characteristics at different stages of development, in sharp contrast to the elongated mitochondria present in somatic cells. We then evaluate the latest transcriptomic data to elucidate the complex functions of mitochondria during oocyte maturation and the impact of mitochondria on oocyte development. Finally, we describe the methodological progress of mitochondrial replacement therapy to rescue oocytes with developmental disorders or mitochondrial diseases, hoping to provide a guiding reference to future clinical applications.

引用

页码：332 / 340

页数：9

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