Catalytic asymmetric de novo construction of 4-pyrrolin-2-ones via intermolecular formal [3+2] cycloaddition of azoalkenes with azlactones

被引：8

作者：

Mo, Nan-Nan ^{[1
,2
]}

Miao, Yu-Hang ^{[1
,2
]}

Xiao, Xiao ^{[3
]}

Hua, Yuan-Zhao ^{[1
,2
]}

Wang, Min-Can ^{[1
,2
]}

Huang, Lihua ^{[1
,2
]}

Mei, Guang-Jian ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

[3] Zhejiang Univ Technol, Inst Pharmaceut Sci & Technol, Hangzhou 310014, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 39期

关键词：

DIELS-ALDER REACTION; ENANTIOSELECTIVE SYNTHESIS; DERIVATIVES; HETEROCYCLES;

D O I：

10.1039/d3cc01194a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chiral phosphoric acid-catalyzed asymmetric intermolecular formal [3+2] cycloaddition of azoalkenes with azlactones has been established. This convergent protocol leads to a facile and enantioselective de novo construction of a wide range of fully substituted 4-pyrrolin-2-ones bearing a fully substituted carbon atom in good yields and with excellent enantioselectivities (26 examples, 72-95% yields and 87-99% ee).

引用

页码：5902 / 5905

页数：4

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