The impact of endometrial scratch performed in mid-luteal phase on the endometrium whole genome transcriptomic profiles in following menstrual cycle

被引：1
|
作者：
Tian, Yichao [1 ]
Huang, Jin [2 ,3 ]
Wang, Chi-Chiu [3 ,4 ,5 ]
Lin, Huizhen [1 ]
Huang, Xiaona [1 ]
Zhao, Yue [1 ]
Liu, Liu [1 ,6 ]
Zhang, Songying [1 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Obstet & Gynecol,Assisted Reprod Unit,Key Lab, Hangzhou, Peoples R China
[2] Chinese Univ Hong Kong, Affiliated Hosp 2, Dept Obstet & Gynecol, Shenzhen, Peoples R China
[3] Chinese Univ Hong Kong, Dept Obstet & Gynecol, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Hong Kong Sichuan Univ, Joint Lab Reprod Med, Sch Biomed Sci, Hong Kong, Peoples R China
[5] Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China
[6] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Obstet & Gynecol,Assisted Reprod Unit,Key Lab, 3 Qingchun East Rd, Hangzhou 310016, Peoples R China
来源：
HUMAN FERTILITY | 2023年 / 26卷 / 04期
关键词：
Recurrent implantation failure; endometrial scratch; endometrial receptivity; genomic profile; embryo transfer; window of implantation; IN-VITRO FERTILIZATION; RANDOMIZED CONTROLLED-TRIAL; EMBRYO-TRANSFER CYCLE; IMPLANTATION FAILURE; LOCAL INJURY; PREGNANCY RATES; UNEXPLAINED INFERTILITY; SUBFERTILE WOMEN; HYSTEROSCOPY; EXPRESSION;
D O I：
10.1080/14647273.2023.2193909
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The value of endometrial scratch in women with recurrent embryo transfer has been controversial. Endometrial scratch is often performed in the mid-luteal phase of the cycle preceding embryo transfer but there is little scientific evidence if it affects the whole genome transcriptomic profile of peri-implantation endometrium in the following cycle. A prospective longitudinal cohort study was conducted in a university assisted reproductive unit. A total of eight women with recurrent implantation failure (RIF) were included. Each participant had endometrial biopsy twice, first biopsy on day LH + 7 in natural cycle and second on day LH + 7 of the following cycle. R package was used to identify differentially expressed genes between the sample and enriched gene ontology. However, the paired sample showed no significant difference, neither known endometrial receptive gene set nor other genes, before and after the endometrial scratch. It suggests that endometrial scratch performed during previous mid-luteal phase did not affect the transcriptomic profiles of endometrium on day LH + 7 in women with RIF.
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收藏
页码：733 / 741
页数：9
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