Palladium-Catalyzed C-H Allylation/Annulation Reaction of Amides and Allylic Alcohols: Regioselective Construction of Vinyl-Substituted 3,4-Dihydroisoquinolones

被引：6
|
作者：
Wu, Haijian [1 ,2 ]
Gui, Jing [1 ,2 ]
Sun, Manman [1 ,2 ]
Ma, Yongmin [1 ,2 ]
Yang, Jianguo [1 ,2 ]
Wang, Zhiming [1 ,2 ]
机构：
[1] Taizhou Univ, Adv Res Inst, Jiaojiang 318000, Zhejiang, Peoples R China
[2] Taizhou Univ, Sch Pharmaceut Sci, Jiaojiang 318000, Zhejiang, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 06期
关键词：
ONE-POT; ASYMMETRIC-SYNTHESIS; DIRECTING-GROUP; ALKYLATION; ALLYLATION; FUNCTIONALIZATION; ACTIVATION; ANNULATION; INDOLES; ACCESS;
D O I：
10.1021/acs.joc.3c00124
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed highly regioselective C-H allylation/annulation reaction of N-sulfonyl amides with secondary or tertiary allylic alcohols has been developed to construct 3,4-dihydroisoquinolones bearing a synthetically valuable vinyl substituent. This cascade cyclization approach of allylic alcohols involving C-H allylation has not been reported previously. The commercially available allylic alcohol substrates, the only by-product of water, and the used terminal oxidant of O2 provide environmentally benign advantages.
引用
收藏
页码：3871 / 3882
页数：12
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