Identification of triterpenoid saponin inhibitors of interleukin (IL)-33 signaling from the roots of Astragalus membranaceus

被引:10
|
作者
Vinh, Le Ba [1 ,2 ]
Han, Yoo Kyong [1 ]
Park, Si Young [1 ]
Kim, Young Jun [1 ]
Phong, Nguyen Viet [2 ]
Kim, Eunji [3 ]
Ahn, Bong-geun [1 ,3 ]
Jung, Yong Woo [1 ]
Byun, Youngjoo [1 ]
Jeon, Young Ho [1 ]
Lee, Ki Yong [1 ]
机构
[1] Korea Univ, Coll Pharm, Sejong 30019, South Korea
[2] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem IMBC, 18 Hoang Quoc Viet, Hanoi, Vietnam
[3] Azcuris Co Ltd, Res & Business Cooperat Bldg,2511 Sejong Ro, Sejong 30019, South Korea
基金
新加坡国家研究基金会;
关键词
Astragalus membranaceus; Anti-inflammatory; Triterpenoid saponin; IL-33; ALLERGIC DISEASES; GLYCOSIDES; CONSTITUENTS; PTEROCARPAN;
D O I
10.1016/j.jff.2023.105418
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Interleukin-33 (IL-33) is a cytokine produced by epithelial cells that plays a key role in immune-mediated dis-eases, such as asthma, atopic dermatitis, and rheumatoid arthritis. In our research on the anti-allergic effects of Korean medicinal plants, we found that an ethanol extract from the roots of Astragalus membranaceus exhibited a significant IL-33 inhibitory effect. Using various chromatographic separation methods, eight compounds (1-8) were isolated from the extract. The inhibitory effect of the isolated compounds on the IL-33 protein was also investigated by ELISA. Compounds 1, 5, and 6 showed significant IL-33 inhibitory activity. Moreover, molecular docking and molecular dynamic simulations of two active compounds supported the in vitro results. Taken together, these results suggest that triterpenoid saponins from A. membranaceus roots might be useful for their pharmacological anti-allergic effects.
引用
收藏
页数:10
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