Metal-Free Synthesis of Functionalized Quinolines from 2-Styrylanilines and 2-Methylbenzothiazoles/2-Methylquinolines

被引:2
|
作者
Liu, Xiaoying [1 ]
Chu, Xianglong [1 ]
机构
[1] Xinjiang Normal Univ, Sch Chem & Chem Engn, Urumqi 830054, Peoples R China
来源
ACS OMEGA | 2023年 / 8卷 / 07期
关键词
BOND FUNCTIONALIZATION; NITROGEN-HETEROCYCLES; POLYSUBSTITUTED QUINOLINES; QUINAZOLINE; CYCLIZATION; CLEAVAGE; ADJACENT; PYRIDINE; ECONOMY; OXYGEN;
D O I
10.1021/acsomega.2c07736
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A facile functionalization of C(sp3)-H bonds and tandem cyclization strategy to synthesize quinoline derivatives from 2-methylbenzothiazoles or 2-methylquinolines and 2styrylanilines has been developed. This work avoids the requirement for transition metals, offering a mild approach to activation of C(sp(3))-H bonds and formation of new C-C and C-N bonds. This strategy features excellent functional group tolerance and scaled-up synthetic capability, thus providing an efficient and environmentally friendly access to medicinally valuable quinolines.
引用
收藏
页码:6940 / 6944
页数:5
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