Enantioselective synthesis of tricyclic oxoquinolines via NHC-catalyzed Michael-aldol-lactamization-dehydration cascade

被引：0
|
作者：
Barik, Shilpa [1 ]
Sankar, Ganga [1 ]
Biju, Akkattu T. [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, India
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 32期
关键词：
CARBENE CATALYSIS; ANNULATION; ACCEPTORS; ALDEHYDES;
D O I：
10.1039/d4cc00502c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The enantioselective synthesis of tricyclic oxoquinolines via NHC-catalyzed cascade reaction of enals with malonates bearing a 2-aminophenyl group is reported. The chiral alpha,beta-unsaturated acylazoliums underwent a smooth Michael-aldol-lactamization-dehydration quadruple cascade with the amino malonate derivative to afford the desired tricyclic products.
引用
收藏
页码：4290 / 4293
页数：5
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