SARS-CoV-2 omicron BA.1.1 is highly resistant to antibody neutralization of convalescent serum from the origin strain

被引:3
|
作者
Li, Jianhua [1 ]
Li, Xiaoyan [1 ]
Mao, Haiyan [1 ]
Huang, Chen [1 ]
Sun, Yi [1 ]
Miao, Liangbin [2 ]
Li, Jiaxuan [3 ]
Song, Wanchen [4 ]
Zhang, Yanjun [1 ]
Huang, Jinsong [2 ]
Chen, Keda [3 ]
机构
[1] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China
[2] Zhejiang Univ, Affiliated Hangzhou Xixi Hosp, Sch Med, Dept Hepatol, Hangzhou, Peoples R China
[3] Zhejiang Shuren Univ, Shulan Int Med Coll, Hangzhou, Peoples R China
[4] Zhejiang Chinese Med Univ, Sch Med Technol & Informat Engn, Hangzhou, Peoples R China
关键词
D O I
10.1016/j.virusres.2023.199131
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The emergence and rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (BA.1.1) has attracted global attention. The numerous mutations in the spike protein suggest that it may have altered susceptibility to immune protection elicited by the existing coronavirus disease 2019 (COVID-19) infection. We used a live virus neutralization test and SARS-CoV-2 pseudotype vesicular stomatitis virus vector-based neutralization assay to assess the degree of immune escape efficiency of the original, Delta (B1.617.2), and Omicron strains against the serum antibodies from 64 unvaccinated patients who had recovered from COVID-19 and the results were strongly correlated. The convalescent serum neutralization was more markedly reduced against the Omicron variant (9.4-57.9-fold) than the Delta variant (2.0-4.5-fold) as compared with the original strain. Our results demonstrate the reduced fusion and notable immune evasion capabilities of the Omicron variants, highlighting the importance of accelerating the development of vaccines targeting them.
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页数:8
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