Psychosocial outcomes in long-term Dutch adult survivors of childhood cancer: The DCCSS-LATER 2 psycho-oncology study

被引：6

作者：

Maas, Anne ^{[1
,11
]}

Maurice-Stam, Heleen ^{[1
]}

Kremer, Leontien C. M. ^{[1
,2
]}

van der Aa-van Delden, Alied ^{[1
]}

van Dulmen-den Broeder, Eline ^{[3
]}

Tissing, Wim J. E. J. ^{[1
,4
]}

Loonen, Jacqueline ^{[5
]}

van der Pal, Helena J. H. ^{[1
]}

de Vries, Andrica C. H. M. ^{[1
,6
]}

van den Heuvel-Eibrink, Marry ^{[1
,6
]}

Ronckers, Cecile ^{[1
,7
]}

Neggers, Sebastian ^{[1
,8
]}

Bresters, Dorine ^{[1
,9
]}

Louwerens, Marloes ^{[10
]}

van der van der Loo, Margriet ^{[1
]}

van Gorp, Marloes ^{[1
]}

Grootenhuis, Martha ^{[1
]}

机构：

[1] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[2] Univ Amsterdam, Dept Pediat, Amsterdam UMC, Amsterdam, Netherlands

[3] Amsterdam UMC locat VUmc, Amsterdam, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Groningen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

[6] Erasmus MC, Sophia Childrens Hosp, Rotterdam, Netherlands

[7] Carl von Ossietzky Univ Oldenburg, Sch Med & Hlth Sci, Dept Hlth Serv Res, Oldenburg, Germany

[8] Erasmus MC, Dept Med, Sect Endocrinol, Rotterdam, Netherlands

[9] Leiden Univ, Willem Alexander Childrens Hosp, Med Ctr, Leiden, Netherlands

[10] Leiden Univ, Med Ctr, Leiden, Netherlands

[11] Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands

来源：

CANCER | 2023年 / 129卷 / 16期

关键词：

anxiety; childhood cancer survivors; cohort study; depression; distress; health-related quality of life; post-traumatic stress; self-esteem; QUALITY-OF-LIFE; POSTTRAUMATIC-STRESS-DISORDER; HOSPITAL ANXIETY; PSYCHOLOGICAL OUTCOMES; SOCIAL SUPPORT; HEALTH-STATUS; DISTRESS; PREDICTORS; POPULATION; VALIDATION;

D O I：

10.1002/cncr.34795

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background This study compares a comprehensive range of psychosocial outcomes of adult childhood cancer survivors (CCS) to general population-based references and identifies sociodemographic and medical risk factors.Methods CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963-2001) part 2 (attained age >= 18 years, diagnosed <18 years, >= 5 years since diagnosis) completed the Rosenberg Self-Esteem Scale, Hospital Anxiety and Depression Scale, Distress Thermometer, Self-Rating Scale for Post-Traumatic Stress Disorder, and the Short Form-36 (Health Related Quality of Life). CCS' scores were compared with references using analysis of variances and logistic regression analysis, controlling for age and sex (p < .05). Risk factors for worse psychosocial outcomes were assessed with regression analyses (p < .05).Results CCS, N = 1797, mean age 35.4 years, 49.0% female, all >= 15 years since diagnosis, participated. Three percent reported posttraumatic stress disorder because of childhood cancer and 36.6% experienced clinical distress. CCS did not differ from references on self-esteem and anxiety but were less depressed (d = -.25), and scored poorer on all health-related quality of life scales, except for bodily pain (.01 <= d >= -.36). Female sex, lower educational attainment, not being in a relationship, and being unemployed were negatively associated with almost all psychosocial outcomes. Except for a central nervous system tumor diagnosis, few medical characteristics were associated with psychosocial outcomes.Conclusion CCS appear resilient regarding mental health but have slightly poorer health-related quality of life than references. Sociodemographic characteristics and central nervous system tumors were related to most psychosocial outcomes, but no clear pattern was observed for other medical factors. Future studies should address additional factors in explaining CCS' psychosocial functioning, such as coping, social support, and physical late effects.

引用

页码：2553 / 2567

页数：15

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