Adipose tissue at single-cell resolution

被引：68
|
作者：
Maniyadath, Babukrishna [1 ]
Zhang, Qianbin [2 ,3 ]
Gupta, Rana K. [2 ,4 ]
Mandrup, Susanne [1 ]
机构：
[1] Univ Southern Denmark, Ctr Funct Genom & Tissue Plast, Dept Biochem & Mol Biol, Odense, Denmark
[2] UT Southwestern Med Ctr, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA
[3] Broad Inst MIT & Harvard, Cambridge, MA USA
[4] Duke Univ, Duke Mol Physiol Inst, Dept Med, Div Endocrinol, Durham, NC 27708 USA
来源：
CELL METABOLISM | 2023年 / 35卷 / 03期
基金：
美国国家卫生研究院; 新加坡国家研究基金会;
关键词：
ADIPOCYTE PROGENITOR CELLS; INDUCED BROWN ADIPOCYTES; GENE-EXPRESSION; WEIGHT-LOSS; FAT-CELLS; MESOTHELIAL CELLS; SUBCUTANEOUS FAT; MESSENGER-RNA; WHITE; OBESITY;
D O I：
10.1016/j.cmet.2023.02.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological conditions. The emergence of single-cell transcriptomics has rapidly transformed our understanding of the diverse array of cell types and cell states residing in adipose tissues and has provided insight into how transcriptional changes in individual cell types contribute to tissue plas-ticity. Here, we present a comprehensive overview of the cellular atlas of adipose tissues focusing on the biological insight gained from single-cell and single-nuclei transcriptomics of murine and human adipose tissues. We also offer our perspective on the exciting opportunities for mapping cellular transitions and crosstalk, which have been made possible by single-cell technologies.
引用
收藏
页码：386 / 413
页数：28
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