Regio- and diastereoselective synthesis of new dispirocyclopentanebisoxindoles using a three-component strategy

被引：4

作者：

Moghaddam, F. Matloubi ^{[1
]}

Aghamiri, Bagher ^{[1
]}

Badpa, Sara ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Lab Organ Synth & Nat Prod, Azadi St,POB, 111559516, Tehran, Iran

来源：

TETRAHEDRON | 2023年 / 141卷

关键词：

Dispirocyclopentanebisoxindoles; Isatin derivatives; Green conditions; SPIROOXINDOLE; CONSTRUCTION; POTENT; BISPIROOXINDOLES; CYCLOADDITION; SCAFFOLD; DESIGN;

D O I：

10.1016/j.tet.2023.133495

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and facile one-pot, multi-component reaction for the regio- and diastereoselective synthesis of novel dispirocyclopentanebisoxindoles has been reported by a reaction between phenyl-2(triphenylphosphoranylidene)ethanone and isatin derivatives. The great advantages of this synthetic protocol are the minimal reaction steps, short reaction time, and operational simplicity. In consequence, a variety of new dispirocyclopentanebisoxindole derivatives with potential medicinal applications were synthesized through one-pot and multi-component reaction in high to excellent yields.& COPY; 2023 Elsevier Ltd. All rights reserved.

引用

页数：10

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