Synthetic methodology of pyrimido[4,5-b]quinoline derivatives

被引：0

作者：

Tawfeek, Hendawy N. ^{[1
,4
]}

Hasanin, Tamer H. A. ^{[2
]}

Braese, Stefan ^{[3
,5
]}

机构：

[1] Minia Univ, Fac Sci, Chem Dept, El Minia, Egypt

[2] Jouf Univ, Dept Chem, Coll Sci, Sakaka, Saudi Arabia

[3] Karlsruhe Inst Technol, Inst Biol & Chem Syst, IBCS FMS, Karlsruhe, Germany

[4] Minia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt

[5] Karlsruhe Inst Technol, Inst Biol & Chem Syst, IBCS FMS, D-76131 Karlsruhe, Germany

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2024年 / 61卷 / 06期

关键词：

ONE-POT SYNTHESIS; SULFONIC-ACID-CHLORIDE; EFFICIENT CATALYST; IONIC LIQUID; 5-DEAZAFLAVIN DERIVATIVES; MULTICOMPONENT SYNTHESIS; 3-COMPONENT REACTION; ANALGESIC ACTIVITY; ANTITUMOR AGENTS; FACILE SYNTHESIS;

D O I：

10.1002/jhet.4815

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review discusses the synthetic pathways of an important class of quinolines known as pyrimido[4,5-b]quinoline. Due to their profound range as biologically active compounds, they attracted the attention of medical/organic researchers. The construction of pyrimido[4,5-b]quinolines involved the intermolecular cyclization of diamino chloropyrimidine carbaldehyde and intramolecular cyclization of 2-amino-3-cyanotetra/hexahydroquinoline, 2-aminoquinoline-3-carbonitriles, ester or amide. That class of organic compounds was constructed from the reaction between 2-chloro-3-formylquinoline with amidine, urea, and thiourea. Also, barbituric acid and uracil and their analogous play an important role in synthesizing pyrimidoquinolines via multicomponent reaction strategies (MCR).

引用

页码：971 / 1008

页数：38

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