Synthetic methodology of pyrimido[4,5-b]quinoline derivatives

被引：0
|
作者：
Tawfeek, Hendawy N. [1 ,4 ]
Hasanin, Tamer H. A. [2 ]
Braese, Stefan [3 ,5 ]
机构：
[1] Minia Univ, Fac Sci, Chem Dept, El Minia, Egypt
[2] Jouf Univ, Dept Chem, Coll Sci, Sakaka, Saudi Arabia
[3] Karlsruhe Inst Technol, Inst Biol & Chem Syst, IBCS FMS, Karlsruhe, Germany
[4] Minia Univ, Fac Sci, Chem Dept, El Minia 61519, Egypt
[5] Karlsruhe Inst Technol, Inst Biol & Chem Syst, IBCS FMS, D-76131 Karlsruhe, Germany
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2024年 / 61卷 / 06期
关键词：
ONE-POT SYNTHESIS; SULFONIC-ACID-CHLORIDE; EFFICIENT CATALYST; IONIC LIQUID; 5-DEAZAFLAVIN DERIVATIVES; MULTICOMPONENT SYNTHESIS; 3-COMPONENT REACTION; ANALGESIC ACTIVITY; ANTITUMOR AGENTS; FACILE SYNTHESIS;
D O I：
10.1002/jhet.4815
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This review discusses the synthetic pathways of an important class of quinolines known as pyrimido[4,5-b]quinoline. Due to their profound range as biologically active compounds, they attracted the attention of medical/organic researchers. The construction of pyrimido[4,5-b]quinolines involved the intermolecular cyclization of diamino chloropyrimidine carbaldehyde and intramolecular cyclization of 2-amino-3-cyanotetra/hexahydroquinoline, 2-aminoquinoline-3-carbonitriles, ester or amide. That class of organic compounds was constructed from the reaction between 2-chloro-3-formylquinoline with amidine, urea, and thiourea. Also, barbituric acid and uracil and their analogous play an important role in synthesizing pyrimidoquinolines via multicomponent reaction strategies (MCR).
引用
收藏
页码：971 / 1008
页数：38
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