Brain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review

被引：3
|
作者：
Yang, Caiting [1 ]
Wang, Haojun [1 ]
Shao, Miaomiao [2 ]
Chu, Fengyu [1 ]
He, Yuyu [1 ]
Chen, Xiaoli [1 ]
Fan, Jiahui [1 ]
Chen, Jingwen [1 ]
Cai, Qianqian [3 ]
Wu, Changxin [1 ]
机构：
[1] Shanxi Univ, Inst Biomed Sci, Taiyuan 030006, Peoples R China
[2] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Nanjing 210023, Peoples R China
[3] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China
来源：
CELLS | 2024年 / 13卷 / 03期
关键词：
brain-type glycogen phosphorylase (PYGB); glycogen phosphorylase; glycogen metabolism; pathology of diseases; ACUTE MYOCARDIAL-INFARCTION; ISOENZYME-BB; INTESTINAL METAPLASIA; PROLIFERATIVE ZONE; HUMAN STOMACH; EXPRESSION; DIAGNOSIS; METABOLISM; CANCER; LIVER;
D O I：
10.3390/cells13030289
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Glycogen metabolism is a form of crucial metabolic reprogramming in cells. PYGB, the brain-type glycogen phosphorylase (GP), serves as the rate-limiting enzyme of glycogen catabolism. Evidence is mounting for the association of PYGB with diverse human diseases. This review covers the advancements in PYGB research across a range of diseases, including cancer, cardiovascular diseases, metabolic diseases, nervous system diseases, and other diseases, providing a succinct overview of how PYGB functions as a critical factor in both physiological and pathological processes. We present the latest progress in PYGB in the diagnosis and treatment of various diseases and discuss the current limitations and future prospects of this novel and promising target.
引用
收藏
页数：22
相关论文
共 50 条
  • [21] Artificial intelligence for brain diseases: A systematic review
    Segato, Alice
    Marzullo, Aldo
    Calimeri, Francesco
    De Momi, Elena
    APL BIOENGINEERING, 2020, 4 (04):
  • [22] Carcinogenesis of intestinal-type gastric cancer and colorectal cancer is commonly accompanied by expression of brain (fetal)-type glycogen phosphorylase
    Shimada, S
    Tashima, S
    Yamaguchi, K
    Matsuzaki, H
    Ogawa, M
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 1999, 18 (01): : 111 - 118
  • [23] Glycogen phosphorylase inhibition in type 2 diabetes therapy - A systematic evaluation of metabolic and functional effects in rat skeletal muscle
    Baker, DJ
    Timmons, JA
    Greenhaff, PL
    DIABETES, 2005, 54 (08) : 2453 - 2459
  • [24] Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature
    Zis, Panagiotis
    Mitsikostas, Dimos-Dimitrios
    NEUROBIOLOGY OF THE PLACEBO EFFECT, PT II, 2018, 139 : 443 - 462
  • [25] IMMUNOLOGICAL STUDIES ON GLYCOGEN STORAGE DISEASES TYPE III AND V - DEMONSTRATION OF PRESENCE OF AN IMMUNOREACTIVE PROTEIN IN ONE CASE OF MUSCLE PHOSPHORYLASE DEFICIENCY
    DREYFUS, JC
    ALEXANDRE, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1971, 44 (06) : 1364 - +
  • [26] Review article: Emergency endotracheal intubation in non-traumatic brain pathologies: A systematic review and meta-analysis
    Fouche, Pieter F.
    Stein, Christopher
    Jennings, Paul A.
    Boyle, Malcolm
    Bernard, Stephen
    Smith, Karen
    EMERGENCY MEDICINE AUSTRALASIA, 2019, 31 (04) : 533 - 541
  • [27] Optogenetics in chronic neurodegenerative diseases, controlling the brain with light: A systematic review
    El Hajj, Rojine
    Al Sagheer, Tareq
    Ballout, Nissrine
    JOURNAL OF NEUROSCIENCE RESEARCH, 2024, 102 (04)
  • [28] Brain imaging in myotonic dystrophy type 1 A systematic review
    Okkersen, Kees
    Monckton, Darren G.
    Nhu Le
    Tuladhar, Anil M.
    Raaphorst, Joost
    van Engelen, Baziel G. M.
    NEUROLOGY, 2017, 89 (09) : 960 - 969
  • [29] Brain Inflammatory Marker Abnormalities in Major Psychiatric Diseases: a Systematic Review of Postmortem Brain Studies
    Yang-wen Ai
    Yang Du
    Lei Chen
    Shu-Han Liu
    Qing-shan Liu
    Yong Cheng
    Molecular Neurobiology, 2023, 60 : 2116 - 2134
  • [30] Brain Inflammatory Marker Abnormalities in Major Psychiatric Diseases: a Systematic Review of Postmortem Brain Studies
    Ai, Yang-wen
    Du, Yang
    Chen, Lei
    Liu, Shu-Han
    Liu, Qing-shan
    Cheng, Yong
    MOLECULAR NEUROBIOLOGY, 2023, 60 (04) : 2116 - 2134
12345