Brain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review

被引：3
|
作者：
Yang, Caiting [1 ]
Wang, Haojun [1 ]
Shao, Miaomiao [2 ]
Chu, Fengyu [1 ]
He, Yuyu [1 ]
Chen, Xiaoli [1 ]
Fan, Jiahui [1 ]
Chen, Jingwen [1 ]
Cai, Qianqian [3 ]
Wu, Changxin [1 ]
机构：
[1] Shanxi Univ, Inst Biomed Sci, Taiyuan 030006, Peoples R China
[2] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Nanjing 210023, Peoples R China
[3] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China
来源：
CELLS | 2024年 / 13卷 / 03期
关键词：
brain-type glycogen phosphorylase (PYGB); glycogen phosphorylase; glycogen metabolism; pathology of diseases; ACUTE MYOCARDIAL-INFARCTION; ISOENZYME-BB; INTESTINAL METAPLASIA; PROLIFERATIVE ZONE; HUMAN STOMACH; EXPRESSION; DIAGNOSIS; METABOLISM; CANCER; LIVER;
D O I：
10.3390/cells13030289
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Glycogen metabolism is a form of crucial metabolic reprogramming in cells. PYGB, the brain-type glycogen phosphorylase (GP), serves as the rate-limiting enzyme of glycogen catabolism. Evidence is mounting for the association of PYGB with diverse human diseases. This review covers the advancements in PYGB research across a range of diseases, including cancer, cardiovascular diseases, metabolic diseases, nervous system diseases, and other diseases, providing a succinct overview of how PYGB functions as a critical factor in both physiological and pathological processes. We present the latest progress in PYGB in the diagnosis and treatment of various diseases and discuss the current limitations and future prospects of this novel and promising target.
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页数：22
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