A Novel Polyphenolic Hydrogels Therapeutic Strategy for Diabetic Wounds Repair

被引:0
|
作者
Wang, Chun [1 ]
Qiao, Yi-Xin [2 ,3 ]
Huang, Zhi-Qiang [1 ]
Zeng, Zhen [4 ,5 ]
Pan, Yan [2 ,3 ]
Hu, Xu-Lin [2 ,3 ,6 ,7 ]
Dong, Zhi-Hong [1 ]
机构
[1] Chengdu Univ, Sch Mech Engn, Chengdu 610106, Sichuan, Peoples R China
[2] Chengdu Univ, Clin Med Coll, Chengdu 610106, Sichuan, Peoples R China
[3] Chengdu Univ, Affiliated Hosp, Chengdu 610106, Sichuan, Peoples R China
[4] Sichuan Univ, West China Hosp, Key Lab Rehabil Med Sichuan Prov, Chengdu 610041, Peoples R China
[5] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Zhejiang, Peoples R China
[6] Sichuan Univ, Dept Biotherapy, Canc Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
[7] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
关键词
Polyphenols; Hydrogels; Diabetic Wound; Diabetes Experimental Models; EXTRACELLULAR VESICLES; ADHESIVE; NANOPARTICLES; HEMOSTASIS; DRESSINGS; TOUGH;
D O I
10.1166/jbt.2023.3339
中图分类号
Q813 [细胞工程];
学科分类号
摘要
As we all know, diabetes patients greatly decrease their quality of life and increase their economic burden. Tissue regeneration in diabetic wounds is a worldwide clinical challenge due to immune, genetic, and environmental factors. Severe infectious wounds in diabetic patients can potentially result in sepsis even amputation. Hence, it is necessary to use a rapid treatment strategy for effective anti-infection with hydrogel materials. Polyphenol polymers may quickly suppress reactive oxygen species of chronic inflammation for diabetic wounds. However, the instability of polyphenols reduces the rate of wound healing, using a hydrogel carrier as a carrier can improve the stability of polyphenolic compounds and control their release to accelerate wound healing. This review elaborates on diabetic wound pathogenesis, the therapeutic effect of polyphenolic hydrogel, including its preparation and stability, and the construction of the diabetes model, which provides a reference for the clinical treatment of diabetes.
引用
收藏
页码:953 / 967
页数:15
相关论文
共 50 条
  • [31] Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy
    Nabavi, Seyed Fazel
    Barber, Alistair J.
    Spagnuolo, Carmela
    Russo, Gian Luigi
    Daglia, Maria
    Nabavi, Seyed Mohammad
    Sobarzo-Sanchez, Eduardo
    CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2016, 53 (05) : 293 - 312
  • [32] Suturing White Wounds: Racialized Therapeutic Rhetoric as a Strategy of Whiteness
    Hartzell, Stephanie L.
    SOUTHERN COMMUNICATION JOURNAL, 2023, 88 (04) : 283 - 297
  • [33] Novel therapeutic activities of dragon blood from palm tree Daemonorops draco for the treatment of chronic diabetic wounds
    Chen, Hong-Chi
    You, Ren-In
    Lin, Fang-Mei
    Lin, Guan-Ling
    Ho, Tsung-Jung
    Chen, Hao-Ping
    BOTANICAL STUDIES, 2024, 65 (01)
  • [34] Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications
    Taisescu, Oana
    Dinescu, Venera Cristina
    Rotaru-Zavaleanu, Alexandra Daniela
    Gresita, Andrei
    Hadjiargyrou, Michael
    GELS, 2025, 11 (02)
  • [35] Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds
    Alamoudi, Abdullah A.
    Alharbi, Awaad S.
    Abdel-Naim, Ashraf B.
    Badr-Eldin, Shaimaa M.
    Awan, Zuhier A.
    Okbazghi, Solomon Z.
    Ahmed, Osama A. A.
    Alhakamy, Nabil A.
    Fahmy, Usama A.
    Esmat, Ahmed
    LIFE-BASEL, 2022, 12 (07):
  • [36] Role of Mesenchymal Stem Cells in Dermal Repair in Burns and Diabetic Wounds
    Maranda, Eric L.
    Rodriguez-Menocal, Luis
    Badiavas, Evangelos V.
    CURRENT STEM CELL RESEARCH & THERAPY, 2017, 12 (01) : 61 - 70
  • [37] IFN-κ is critical for normal wound repair and is decreased in diabetic wounds
    Wolf, Sonya J.
    Audu, Christopher O.
    Joshi, Amrita
    DenDekker, Aaron
    Melvin, William J.
    Davis, Frank M.
    Xing, Xianying
    Wasikowski, Rachael
    Tsoi, Lam C.
    Kunkel, Steven L.
    Gudjonsson, Johann E.
    O'Riordan, Mary X.
    Kahlenberg, J. Michelle
    Gallagher, Katherine A.
    JCI INSIGHT, 2022, 7 (09)
  • [38] Novel multifunctional dual-dynamic-bonds crosslinked hydrogels for multi-strategy therapy of MRSA-infected wounds
    Deng, Pengpeng
    Liang, Xiao
    Chen, Feixiang
    Chen, Yun
    Zhou, Jinping
    APPLIED MATERIALS TODAY, 2022, 26
  • [39] NOVEL STRATEGY FOR THERAPEUTIC ANGIOGENSIS
    Minamino, Tohru
    JOURNAL OF GENE MEDICINE, 2014, 16 (7-8): : 211 - 211
  • [40] A novel therapeutic strategy for β-thalassemia
    Townes, Tim M.
    BLOOD, 2019, 133 (21) : 2245 - 2246