Osteoporosis treatment. Systematic review

Osteoporosis is a chronic disease with a wide worldwide distribution. It is considered the disease of the century and mainly affects postmenopausal women; although, men are also affected. The objective of this qualitative systematic review is to highlight the main characteristics of pharmacological and non-pharmacological treatment of osteoporosis. For which a search of documentary information was carried out in PubMed, Scielo and Google Scholar with the use of keywords in English and Spanish, without time restrictions. A total of 55,685 works were found and the PRISMA guide was used to filter the information. For treatment, traditionally the use of oral or intravenous bisphosphonates offer excellent therapeutic alternatives; however, some side effects have been observed due to prolonged use. Other treatment strategies include teriparatide, denosumab, and strontium ranelate. It is a condition treatable with chemotherapy, where the clinician seeks to offer the best possible quality of life to the patient, preventing the most fearsome consequence: fractures. The use of bone metabolism biomarkers is ideal for monitoring treatment efficacy. Osteoporosis is also an excellent area of work for researchers from all over the world, in terms of immunopathogenesis, associated genetic factors and, more recently, epigenetics.