T-large granular lymphocytic leukemia

被引：7
|
作者：
Park, Sang Hyuk [1 ]
Lee, Yoo Jin [2 ]
Kim, Youjin [2 ]
Kim, Hyun-Ki [1 ]
Lim, Ji-Hun [1 ]
Jo, Jae-Cheol [2 ]
机构：
[1] Univ Ulsan, Ulsan Univ Hosp, Dept Lab Med, Ulsan, South Korea
[2] Univ Ulsan, Ulsan Univ Hosp, Dept Hematol & Oncol, Ulsan, South Korea
来源：
BLOOD RESEARCH | 2023年 / 58卷
关键词：
T-cell large granular lymphocyte leukemia; Diagnosis; Treatment; STAT3; MUTATIONS; LGL LEUKEMIA; LYMPHOPROLIFERATIVE DISEASE; CLINICAL-FEATURES; SALVAGE THERAPY; CELL; CYCLOPHOSPHAMIDE; CYCLOSPORINE; SURVIVAL; OUTCOMES;
D O I：
10.5045/br.2023.2023037
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
T-cell large granular lymphocyte (T-LGL) leukemia is characterized by clonal expansion of cytotoxic T cells resulting in cytopenia. The proliferation of clonal LGLs is caused by prolonged antigenic stimulation, which leads to apoptotic dysregulation owing mainly to the constitutive activation of survival pathways, notably the JAK/STAT pathway. Understanding how leukemic T-LGL persists can aid in the development of future immunosuppressive therapies. In this review, we summarize the diagnosis and current standard of therapy for T-LGL leukemia, as well as recent advances in clinical trials.
引用
收藏
页码：52 / 57
页数：6
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