[1] Univ Porto, Fac Med, Dept Biomed, Unit Pharmacol & Therapeut, Rua Placido Costa, P-4200450 Porto, Portugal
[2] Univ Porto, Dept Biomed, CINTESISRISE, Fac Med, Porto, Portugal
[3] Sao Joao Hosp Ctr, Dept Gastroenterol, Porto, Portugal
[4] Sao Joao Hosp Univ Ctr, Clin Pharmacol Unit, Porto, Portugal
[5] Vila Nova De Gaia Espinho Hosp Ctr, Dept Gastroenterol, Vila Nova De Gaia, Portugal