Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores

被引：0

作者：

Chong, Michael ^{[1
,2
,3
,4
]}

Pare, Guillaume ^{[1
,2
,3
,4
,5
]}

机构：

[1] David Braley Cardiac Vasc & Stroke Res Inst, Populat Hlth Res Inst, Hamilton, ON, Canada

[2] David Braley Cardiac Vasc & Stroke Res Inst, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada

[3] McMaster Univ, Michael G DeGroote Sch Med, Dept Pathol & Mol Med, Hamilton, ON, Canada

[4] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

[5] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

来源：

NATURE GENETICS | 2023年 / 55卷 / 03期

关键词：

D O I：

10.1038/s41588-023-01330-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Current risk assessment and treatment strategies for venous thromboembolism (VTE) consider genetic factors only in a limited way. New work shows a more pervasive role of common variants in VTE risk, inspiring genetic predictors that surpass and complement individual clinical risk factors and monogenic thrombophilia testing.

引用

页码：358 / 360

页数：3

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