Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores

被引：0
|
作者：
Chong, Michael [1 ,2 ,3 ,4 ]
Pare, Guillaume [1 ,2 ,3 ,4 ,5 ]
机构：
[1] David Braley Cardiac Vasc & Stroke Res Inst, Populat Hlth Res Inst, Hamilton, ON, Canada
[2] David Braley Cardiac Vasc & Stroke Res Inst, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada
[3] McMaster Univ, Michael G DeGroote Sch Med, Dept Pathol & Mol Med, Hamilton, ON, Canada
[4] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada
[5] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
来源：
NATURE GENETICS | 2023年 / 55卷 / 03期
关键词：
D O I：
10.1038/s41588-023-01330-0
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Current risk assessment and treatment strategies for venous thromboembolism (VTE) consider genetic factors only in a limited way. New work shows a more pervasive role of common variants in VTE risk, inspiring genetic predictors that surpass and complement individual clinical risk factors and monogenic thrombophilia testing.
引用
收藏
页码：358 / 360
页数：3
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