Metal-free construction of dihydropyrazino[2,3-b]indoles from 2-aminoacetophenones, isocyanates and 1,2-diamines

被引：9
|
作者：
Fang, Jingxi [1 ]
Fang, Jiayao [1 ]
Rao, Yingbo [1 ]
Qiu, Huanyi [1 ]
Pan, Zhentao [1 ]
Ma, Yongmin [1 ]
机构：
[1] Taizhou Univ, Inst Adv Studies, 1139 Shifu Ave, Taizhou 318000, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 10期
关键词：
DERIVATIVES; CONVERSION; AZAACENES; SPECTRA; HOST;
D O I：
10.1039/d3ob01967e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Bronsted acid/iodine co-mediated approach to construct dihydropyrazino[2,3-b]indoles in 2-MeTHF as a green solvent at room temperature was established. A wide range of diversely substituted dihydropyrazino[2,3-b]indoles (42 examples, 61-85% yields) were synthesized under mild conditions, even on a gram scale. This protocol features organocatalysts, an eco-friendly solvent, mild conditions, readily accessible substrates, broad substrate scope and simple work-up.
引用
收藏
页码：2043 / 2048
页数：6
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