CCHFV vaccine development, current challenges, limitations, and future directions

被引：6

作者：

Ahata, Busra ^{[1
,2
]}

Akcapinar, Gunseli Bayram ^{[1
]}

机构：

[1] Acibadem Mehmet Ali Aydinlar Univ, Inst Hlth Sci, Dept Med Biotechnol, Istanbul, Turkiye

[2] Hlth Inst Turkey, Istanbul, Turkiye

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

Crimean-Congo hemorrhagic fever virus; vaccines; virus-like particle (VLP); viral vectored vaccines; DNA-based vaccines; mRNA-based vaccines; CONGO HEMORRHAGIC-FEVER; IMMUNE-RESPONSE; VIRUS-INFECTION; VIRAL VECTORS; PATHOGENESIS; PROTEIN; DNA; INTERFERON; EXPRESSION; PROTECTION;

D O I：

10.3389/fimmu.2023.1238882

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a large number of potential vaccine candidates, there are no approved vaccines as of yet. This paper presents a detailed comparative analysis of current efforts to develop vaccines against CCHFV, limitations associated with current efforts, and future research directions.

引用

页数：18

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