Response to aerosolized calfactant in infants with respiratory distress syndrome; a post-hoc analysis of AERO-02 trial

被引：2

作者：

Kaluarachchi, Dinushan C. C. ^{[1
]}

Zapata, Henry A. A. ^{[1
]}

Becker, Heather L. L. ^{[2
]}

Lasarev, Michael R. R. ^{[3
]}

Fort, Prem ^{[4
,5
]}

Guthrie, Scott O. O. ^{[6
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Div Neonatol, Madison, WI 53715 USA

[2] UnityPoint Hlth Meriter Hosp, Dept Resp Therapy, Madison, WI USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI USA

[4] Johns Hopkins Univ, Dept Pediat, Div Neonatol, Sch Med, Baltimore, MD USA

[5] Johns Hopkins All Childrens Hosp, Johns Hopkins All Childrens Maternal Fetal & Neona, St Petersburg, FL USA

[6] Vanderbilt Univ, Dept Pediat, Div Neonatol, Sch Med, Nashville, TN USA

来源：

JOURNAL OF PERINATOLOGY | 2023年 / 43卷 / 08期

关键词：

SURFACTANT REPLACEMENT THERAPY; PRETERM; VENTILATION;

D O I：

10.1038/s41372-023-01717-1

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BackgroundThe aerosolized calfactant decreased the need for intubation in neonates with respiratory distress syndrome (AERO-02 trial).ObjectiveTo determine the oxygenation response to aerosolized calfactant among infants born 28 0/7-36 6/7 weeks with RDS in the AERO-02 trial.MethodsTrends in hourly fraction of oxygen (FiO(2)), mean airway pressure (MAP) and respiratory severity score (RSS) were compared between the aerosolized calfactant (AC) and usual care (UC) groups from time of randomization for 72 h.ResultsA total of 353 subjects were included in the study. FiO(2), MAP, and RSS were lower in the UC group. FiO(2) decrease was seen after the first aerosolized calfactant dose.ConclusionFiO(2), MAP, and RSS were lower in the UC group. This is likely due to early and higher rate of liquid surfactant administration in the UC group. Decrease in FiO(2) was noted in the AC group after the first aerosolization.

引用

页码：998 / 1003

页数：6

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