Neonatal seizures during extra corporeal membrane oxygenation support

To evaluate EEG monitoring during neonatal ECMO and to identify any correlations between seizure detection to abnormal neuroimaging. Eight-year, service evaluation of neonates who received at least one continuous EEG (cEEG) whilst on ECMO at Great Ormond Street Hospital. Pearson's chi-square test and multivariate logistic regression analysis were used to assess clinical and EEG variables association with seizures and neuroimaging findings. Fifty-seven neonates were studied; 57 cEEG recordings were reviewed. The incidence of seizures was 33% (19/57); of these 74% (14/19) were electrographic-only. The incidence of status epilepticus was 42%, (8/19 with 6 neonates having electrographic-only status and 2 electro-clinical status. Seizures were detected within an hour of recording in 84%, (16/19). The overall mortality rate was 39% (22/57). Seizure detection was strongly associated with female gender (OR 4.8, 95% CI: 1.1-20.4, p = 0.03), abnormal EEG background activity (OR 2.8, 95% CI: 1.1-7.4, p = 0.03) and abnormal EEG focal features (OR 23.6, 95% CI: 5.4-103.9, p = 0.001). There was a strong association between the presence of seizures and abnormal neuroimaging findings (OR 10.9, 95% CI: 2.8-41.9, p = 0.001). Neonates were highly likely to have abnormal neuroimaging findings in the presence of severely abnormal background EEG (OR 9.5, 95% CI 1.7-52.02, p = 0.01) and focal EEG abnormalities (OR 6.35, 95% CI 1.97-20.5, p = 0.002)Conclusion: The study highlights the importance of cEEG in neonates undergoing ECMO. An association between seizure detection and abnormal neuroimaging findings was described. What is Known:center dot Patients on ECMO are at a higher risk of seiures.center dot Continuous EEG monitoring is recommended by the ACNS for high risk and ECMO patients.What is New:center dot In this cohort, neonates with sezirues were 11 times more likely of having abnromal neuroimaging findings.center dot Neonates with burst suppressed or suppressed EEG background were 9.5 times more likely to have abnormal neuroimaging findings.What does this study add?center dot This study reports a 33% incidence of neonatal seizures during ECMO.center dot Neonates with seizures were 11 times more likely to have an abnormal brain scan.center dot The study captures the real-time approach of EEG monitoring.center dot Recommended cEEG monitoring should last at least 24 h for ECMO patients.center dot This is the first study to assess this in neonates only.